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由来生物
chicken
品質水準
結合体
unconjugated
抗体製品の状態
affinity isolated antibody
抗体製品タイプ
primary antibodies
クローン
polyclonal
形状
buffered aqueous solution
化学種の反応性
rat, mouse, human
メーカー／製品名
Genway 15-288-21470
テクニック
western blot: suitable
NCBIアクセッション番号
UniProtアクセッション番号
輸送温度
wet ice
保管温度
−20°C
ターゲットの翻訳後修飾
unmodified
遺伝子情報
human ... PPFIA1(8500)
関連するカテゴリー
免疫原
Immunogen Sequence: GI # 4505983, sequence 310-360
Recombinant PTPRF interacting protein α 1 isoform b
アプリケーション
Anti-PPFIA1 (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
生物化学的／生理学的作用
Liprin-α-1 is a cytoplasmic 160kDa phosphoserine protein encoded by the PPFIA1 gene in humans. It encodes liprin α, a protein involved in cell adhesion, integrin expression and cell-matrix interactions. PPFIA1 may act as a potential functional candidate for acute lung injury risk gene for future research. It is frequently co-amplified with the Cyclin D1 gene in oral carcinomas and may present a biomarker as well as a novel target for specific gene therapy. Liprin′s function is to localize LAR family tyrosine phosphatases at specific sites on the plasma membrane. It may help in regulating their interaction with the extracellular environment and their associations with substrates. PPFIA1 may regulate the disassembly of focal adhesions and help to orchestrate cell-matrix interactions.
物理的形状
Solution in phosphate buffered saline containing 0.02% sodium azide.
免責事項
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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保管分類コード
10 - Combustible liquids
WGK
WGK 1
引火点(°F)
Not applicable
引火点(℃)
Not applicable
個人用保護具 (PPE)
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
適用法令
試験研究用途を考慮した関連法令を主に挙げております。化学物質以外については、一部の情報のみ提供しています。 製品を安全かつ合法的に使用することは、使用者の義務です。最新情報により修正される場合があります。WEBの反映には時間を要することがあるため、適宜SDSをご参照ください。
Jan Code
GW21470-BULK:
GW21470-VAR:
GW21470-50UG:
試験成績書（COA）
製品のロット番号・バッチ番号を入力して、試験成績書（COA） を検索できます。ロット番号・バッチ番号は、製品ラベルに「Lot」または「Batch」に続いて記載されています。
Marco Blessmann et al.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 41(8), 845-849 (2013-03-05)
Analyzing chromosomal amplifications delivers valuable information for identification of oncogenes. For carcinomas of the oral cavity only few genes have been identified in amplified regions. The aim of this study was to search genes in amplified regions as possible biomarkers
C Serra-Pagès et al.
The EMBO journal, 14(12), 2827-2838 (1995-06-15)
Focal adhesions are sites of cell-extracellular matrix interactions that function in anchoring stress fibers to the plasma membrane and in adhesion-mediated signal transduction. Both focal adhesion structure and signaling ability involve protein tyrosine phosphorylation. LAR is a broadly expressed transmembrane
Jason D Christie et al.
PloS one, 7(1), e28268-e28268 (2012-02-02)
Acute Lung Injury (ALI) is a syndrome with high associated mortality characterized by severe hypoxemia and pulmonary infiltrates in patients with critical illness. We conducted the first investigation to use the genome wide association (GWA) approach to identify putative risk
C Serra-Pagès et al.
The Journal of biological chemistry, 273(25), 15611-15620 (1998-06-23)
LAR family transmembrane protein-tyrosine phosphatases function in axon guidance and mammary gland development. In cultured cells, LAR binds to the intracellular, coiled coil LAR-interacting protein at discrete ends of focal adhesions, implicating these proteins in the regulation of cell-matrix interactions.
Chikako Nakajima et al.
Nature communications, 15(1), 1877-1877 (2024-03-10)
Axonal growth cones mediate axonal guidance and growth regulation. We show that migrating neurons in mice possess a growth cone at the tip of their leading process, similar to that of axons, in terms of the cytoskeletal dynamics and functional
ライフサイエンス、有機合成、材料科学、クロマトグラフィー、分析など、あらゆる分野の研究に経験のあるメンバーがおります。.
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