D5891

1,1-ジメチル-4-フェニルピペラジニウム ヨウ化物

≥98% (TLC or titration)

• 別名: DMPP
• 実験式（ヒル表記法）: C₁₂H₁₉IN₂
• CAS番号: 54-77-3
• 分子量: 318.20
• Beilstein: 3746109
• EC Number: 200-213-0
• MDL番号: MFCD00011976
• UNSPSCコード: 12352200
• PubChem Substance ID: 24277832
• NACRES: NA.77

特性

• アッセイ: ≥98% (TLC or titration)
• 形状: powder
• mp: 234-238 °C (lit.)
• 溶解性: H₂O: 21 mg/mL
• 保管温度: −20°C
• SMILES記法: [I-].C[N+]1(C)CCN(CC1)c2ccccc2
• InChI: 1S/C12H19N2.HI/c1-14(2)10-8-13(9-11-14)12-6-4-3-5-7-12;/h3-7H,8-11H2,1-2H3;1H/q+1;/p-1
• InChI Key: XFZJGFIKQCCLGK-UHFFFAOYSA-M
• 遺伝子情報: human ... CHRNA1(1134) , CHRNA10(57053) , CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137) , CHRNA5(1138) , CHRNA6(8973) , CHRNA7(1139) , CHRNA9(55584) , CHRNB1(1140) , CHRNB2(1141) , CHRNB3(1142) , CHRNB4(1143) ; rat ... Chrna2(170945) , Chrna3(25101) , Chrna4(25590) , Chrnb2(54239) , Chrnb4(25103)

詳細

アプリケーション

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) has been used as a non-selective nicotinic acetylcholine receptor (nAchR) agonist:

• to study the roles of α7 and α4β2 nAchRs in autonomic regulation of cardiovascular responses in urethane-anesthetized mice
• to study the mechanism involved in improving glucose tolerance in diet-induced obese (DIO) mice treated with DMPP
• to study its pharmacological effect on enteric viscerofugal neurons in the myenteric plexus of guinea-pig colon

生物化学的／生理学的作用

1,1-Dimethyl-4-phenylpiperazinium iodide (DMPP) is a non-selective nicotinic acetylcholine receptor (nAchR) agonist. It acts as a stimulating agent for sympathetic ganglia. DMPP exhibits specific action on ganglia and adrenal medullary tissue hence, it finds its application in the diagnosis of pheochromocytoma.

特徴および利点

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves