B6060

BVT.948

≥98% (HPLC), solid

• 別名: 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
• 実験式（ヒル表記法）: C₁₄H₁₁NO₃
• CAS番号: 39674-97-0
• 分子量: 241.24
• MDL番号: MFCD00616487
• UNSPSCコード: 12352200
• PubChem Substance ID: 24724422
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 保管条件: desiccated; protect from light; under inert gas
• 色: red
• 溶解性: DMSO: 18 mg/mL; H₂O: insoluble
• 保管温度: −20°C
• SMILES記法: CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
• InChI: 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
• InChI Key: BAQXWJQSUXZVIP-UHFFFAOYSA-N

詳細

生物化学的／生理学的作用

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

特徴および利点

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H317
• 注意書き: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危険有害性の分類: Skin Sens. 1
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Faceshields, Gloves