B3811

B-9430 トリフルオロアセタート塩

≥98% (HPLC)

• 別名: D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp³, Igl⁵, D-Igl⁷, Oic⁸]-Bradykinin trifluoroacetate salt
• 実験式（ヒル表記法）: C₆₄H₉₅N₁₉O₁₃ · xC₂HF₃O₂
• CAS番号: 180981-09-3
• 分子量: 1338.56 (free base basis)
• UNSPSCコード: 12352200

特性

• アッセイ: ≥98% (HPLC)
• フォーム: solid
• 保管条件: protect from light; under inert gas
• 溶解性: H₂O: ≥2 mg/mL
• 輸送温度: wet ice
• 保管温度: −20°C

詳細

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg

生物化学的／生理学的作用

B-9430 was developed by Gera at the Stewart laboratory¹ and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA₂ = 8.6) and B1 receptors (pA₂ = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.

Stable, potent, and long lasting Bradykinin (BK) antagonist, which shows high BK antagonism on both B-1 and B-2 receptors.

注意

Product is air and light sensitive. Store in the dark.

安全性情報

• 保管分類コード: 13 - Non Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable