ABE1351

Anti-GATA-6 Antibody

from rabbit, purified by affinity chromatography

• 別名: Transcription factor GATA-6, GATA-binding factor 6
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: affinity isolated antibody
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 精製方法: affinity chromatography
• 化学種の反応性: human
• テクニック: immunocytochemistry: suitable; western blot: suitable
• NCBIアクセッション番号: NP_005248
• UniProtアクセッション番号: Q92908
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... GATA6(2627)

詳細

詳細

GATA-6 is a developmental transcriptional activator important in terminal differentiation and proliferation of cells destined to be associated with the heart, gut and gut related tissues and organs. GATA-6 works in concert with SEMA3C and PLXNA2 transcription factors and regulates the expression of their target genes. GATA-6 is particularly important in heart development as a number of genetic mutations within GATA-6 give rise to defective syndromes involving the heart or the vessels of the heart. Interestingly, recent research into pulmonary hypertension disease in adults points to a critical role of GATA-6 expression in endothelial cells lining the blood vessels. Healthy blood vessels express GATA-6 very strongly but expression is lost during vascular injury and markedly down regulated in the endothelial cells found in diseased vessels. Because GATA-6 is a direct transcriptional regulator or important vascular proteins such as endothelin-1 receptor, endothelial nitric oxide synthase, and cytokines such as Fractalkine, GATA-6’s role in modulating the affects of pulmonary hypertension and other vascular syndromes is a subject of much research.

特異性

Recognizes GATA-6

免疫原

Epitope: Region between amino acid positions 250-500.

Set of 3 peptides designed against isoform 1 located between position 250-500). Note that peptide sequences used are also present in the isoform 2.

アプリケーション

Research Category
エピジェネティクス及び核内機能分子

Research Sub Category
転写因子

Immunocytochemistry Analysis: A representative lot of this antibody has been reported to detect GATA-6 in HeLa, 293T, Capan-2, and SH-SY5Ycells.

This Anti-GATA-6 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of GATA-6.

品質

Evaluated by Western Blotting in PC3 cell lysate.

Western Blotting Analysis: A 2 µg/mL dilution of this antibody detected GATA-6 in PC3cell lysate.

ターゲットの説明

~ 62 kDa observed

物理的形状

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with 0.05% sodium azide.

保管および安定性

Stable for 1 year at 2-8°C from date of receipt.

その他情報

Concentration: Please refer to lot specific datasheet.

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 12 - Non Combustible Liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable