AB16528

Anti-NIK Antibody, CT

Chemicon^®, from rabbit

• 別名: NFkB inducing Kinase
• UNSPSCコード: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

特性

• 由来生物: rabbit
• 品質水準: 100
• 抗体製品の状態: purified immunoglobulin
• 抗体製品タイプ: primary antibodies
• クローン: polyclonal
• 化学種の反応性: human
• メーカー／製品名: Chemicon^®
• テクニック: western blot: suitable
• NCBIアクセッション番号: NM_003954.2
• UniProtアクセッション番号: Q99558
• 輸送温度: wet ice
• ターゲットの翻訳後修飾: unmodified
• 遺伝子情報: human ... MAP3K14(9020)

詳細

特異性

Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli including IL-1, TNFalpha, LPS and mitogens. A serine/threonine protein kinase which mediates NF-kB activation by IL-1, TNFa and CD95 was identified recently and designated NIK (for NF-kB inducing kinase) (Malinin et al. 1997). NIK is an activator of IkB kinase alpha and beta (IKKalpha and IKKbeta) (Regnier et al. 1997; Woronicz et al. 1997; Ling et al. 1998; Nakano et al. 1998). Therefore, NIK is a key molecule in the NF-kB signaling pathway leading to the induction of a variety of gene expression in response to proinflammatory cytokines and bacteria products.

免疫原

Epitope: C-terminus

Rabbit anti-NIK polyclonal antibody was raised against a peptide corresponding to amino acids 931 to 947 of human NIK (Malinin et al. 1997).

アプリケーション

Research Category
細胞シグナル伝達

Research Sub Category
細胞骨格シグナル伝達

Anti-NIK Antibody, C-terminus is an antibody against NIK for use in WB.

Western blot

293 cell lysate can be used as positive control.

Optimal working dilutions must be determined by end user.

物理的形状

Format: Purified

Purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.

保管および安定性

Maintain at 2-8°C in undiluted aliquots for up to 12 months.

その他情報

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法的情報

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免責事項

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全性情報

• 保管分類コード: 10 - Combustible liquids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable