676377

Valinomycin, Streptomyces fulvissimus

A cyclododecadepsi-peptide ionophore antibiotic.

• 別名: Valinomycin, Streptomyces fulvissimus
• 実験式（ヒル表記法）: C₅₄H₉₀N₆O₁₈
• CAS番号: 2001-95-8
• 分子量: 1111.32
• MDL番号: MFCD00005114
• UNSPSCコード: 12352200

特性

• 品質水準: 200
• アッセイ: ≥93% (HPLC)
• 形状: crystalline solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze
• 色: white
• 溶解性: DMSO: soluble; acetic acid: soluble; chloroform: soluble; ether: soluble
• 輸送温度: ambient
• 保管温度: 10-30°C
• InChI: 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34+,35+,36?,37-,38-,39-,40+,41+,42+/m0/s1
• InChI Key: FCFNRCROJUBPLU-UYBNATROSA-N

詳細

詳細

A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore of the mobile ion-carrier type that transports alkali metal ions across artificial or biological lipid membranes. Induces K⁺ conductivity in cell membranes at concentrations as low as 10^-8 M. Often used in membrane electrode systems for determining K⁺ concentration. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.

A cyclododecadepsi-peptide ionophore antibiotic. Potassium ionophore that transports alkali metal ions across artificial or biological lipid membranes (Rb⁺ >K⁺ >Cs⁺ >Ag⁺ >NH₄⁺ >Na⁺ >Li⁺). Induces K⁺ conductivity in cell membranes at concentrations as low as 10 nM. Because of its ability to affect membrane transport of K⁺ and to create a hydrophobic layer on solid electrodes, it is often used in membrane electrode systems for determining K⁺ concentration. Useful in studies of K⁺ transport in mitochondria. Uncouples oxidative phosphorylation by binding to sites on membranes rich in sulfhydryl groups. Induces apoptosis in murine thymocytes. Also reported to inhibit NGF-induced neuronal differentiation.

生物化学的／生理学的作用

Cell permeable: no

Primary Target
NGF-induced neuronal differentiation

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Highly Toxic (H)

その他情報

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Harada, H., et al. 1994. Biochim. Biophys. Acta1220, 310.
Luvisetto, S., et al. 1994. Biochim. Biophys. Acta 1186, 12.
Orlov, V.N., et al. 1994. FEBS Lett.345, 104.
Acra, S., et al. 1993. Am. J. Physiol.264, G45.
Cornet, M., et al. 1993. J. Membr. Biol.131, 55.
Deckers, C.L., et al. 1993. Exp. Cell Res.208, 362.
Dimroth, P., and Thomer, A. 1993. Biochemistry32, 1734.
Opanasenko, V.K., et al. 1992. FEBS Lett.307, 280.
Pape, P.C., et al. 1992. J. Physiol.449, 219.
Ahmed, S., and Booth, I.R. 1983. Biochem. J.212, 105.
Lerner, A., et al. 1982. FEBS Lett.146, 9.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• ピクトグラム: GHS06
• シグナルワード: Danger
• 危険有害性情報: H300 + H310
• 注意書き: P262 - P264 - P280 - P301 + P310 - P302 + P352 + P310 - P361 + P364
• 危険有害性の分類: Acute Tox. 1 Dermal - Acute Tox. 1 Oral
• 保管分類コード: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable