5.08510

ZD 7288

• 別名: ZD 7288, 4-(N-ethyl-N-phenylamino)-1,2-dimethyl-6-(methylamino)pyrimidiniumchloride, Zeneca, HCN Channel Blocker, ZD 7288, ZD-7288, ZD7288
• 実験式（ヒル表記法）: C₁₅H₂₁ClN₄
• CAS番号: 133059-99-1
• 分子量: 292.81
• UNSPSCコード: 12352200
• NACRES: NA.77

特性

• アッセイ: ≥98% (HPLC)
• 品質水準: 100
• 形状: solid
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: water: 100 mM
• 保管温度: 2-8°C
• InChI: 1S/C15H20N4.ClH/c1-5-19(13-9-7-6-8-10-13)15-11-14(16-3)18(4)12(2)17-15;/h6-11H,5H2,1-4H3;1H
• InChI Key: DUWKUHWHTPRMAP-UHFFFAOYSA-N

詳細

詳細

ZD7288 is a potent HCN blocker of hyperpolarization-activated cyclic nucleotide-gated channels (HCN channels) in heart and brain tissue. Recently shown to also block Na⁺ currents in DRG neurons and in HEK293 cells transfected with Na(v)1.4 plasmids. In voltage clamp experiments, it is shown to reduce Ih in a time- and concentration-dependent manner (IC50 = 2 mM). Suggested to behave as a lipophilic quaternary cation that can pass into the cell interior to block Ih channels in their closed state.

生物化学的／生理学的作用

Primary Target
HCN channel

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

その他情報

Pleasenote that the molecular weight for this compound is batch-specific due tovariable water content.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable