208923

CaMKII Inhibitor XII

• 別名: CaMKII Inhibitor XII, Ca ²⁺/Calmodulin-Dependent Protein Kinase II Inhibitor XII
• 実験式（ヒル表記法）: C₂₉H₃₀ClN₅O₂S
• 分子量: 548.10
• UNSPSCコード: 12352200
• NACRES: NA.28

特性

• アッセイ: ≥99% (HPLC)
• 品質水準: 100
• 形状: powder
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; protect from light
• 色: white
• 溶解性: DMSO: 100 mg/mL
• 輸送温度: wet ice
• 保管温度: 2-8°C

詳細

詳細

A pyrimidinyl sulfonamide compound that acts as a potent, reversible and CaM non-competitive inhibitor of CaMKII activities (IC₅₀ = 0.063 µM) with excellent selectivity over several kinases (IC₅₀ = >60, 36, 11, 30 and 21 µM for CaMKIV, MLCK, p38α, Akt1 and PKC, respectively). Shown to exhibit ~25-fold greater potency towards CaMKII than the CaM-competitive inhibitor KN-93 (Cat. No. 422708).

包装

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

再構成

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

その他情報

Asano, S., et al. 2010. Bioorg. Med. Chem. Lett.20, 6696.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 2
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable