208711

Ca²⁺/Calmodulin Kinase II Inhibitor 281-309

The Ca²⁺/Calmodulin Kinase II Inhibitor 281-309 controls the biological activity of Ca²⁺/Calmodulin Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 別名: Ca²⁺/Calmodulin Kinase II Inhibitor 281-309, CaM Kinase II Inhibitor 281-309, MHRQETVDCLKKFNARRKLKGAILTTMLA-OH
• 実験式（ヒル表記法）: C₁₄₆H₂₅₄N₄₆O₃₉S₃
• 分子量: 3374.06
• UNSPSCコード: 12352200

特性

• 品質水準: 100
• アッセイ: ≥97% (HPLC)
• フォーム: lyophilized solid
• 有効性: 80 nM IC₅₀
• メーカー／製品名: Calbiochem^®
• 保管条件: OK to freeze; desiccated (hygroscopic)
• 溶解性: water: 5 mg/mL
• 輸送温度: ambient
• 保管温度: −20°C

詳細

詳細

A synthetic peptide containing the calmodulin binding site (290-309) and the autophosphorylation site (Thr²⁸⁶) of CaM kinase II. Can be phosphorylated at Thr²⁸⁶ by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II by blocking Ca²⁺/calmodulin activation (IC₅₀ = 80 nM) and enzyme-active site (IC₅₀ = 2 µM).

A synthetic peptide that contains the CaM-binding, inhibitory, and autophosphorylation domains of CaM kinase II. Can be phosphorylated at Thr²⁸⁶ by PKC. Useful as a calmodulin binding peptide. Inhibits CaM kinase II (IC₅₀ = 80 nM) by blocking Ca²⁺/calmodulin activation and enzyme active site (IC₅₀ = 2 µM).

生物化学的／生理学的作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

包装

Yes

警告

Toxicity: Standard Handling (A)

シーケンス

H-Met-His-Arg-Gln-Glu-Thr-Val-Asp-Cys-Leu-Lys-Lys-Phe-Asn-Ala-Arg-Arg-Lys-Leu-Lys-Gly-Ala-Ile-Leu-Thr-Thr-Met-Leu-Ala-OH

その他情報

Waxham, M.N., et al. 1993. Biochemistry32, 2923.
Waxham, M.N., et al. 1993. Brain Res. 609, 1.
Fukunaga, K., et al. 1990. J. Neurochem.54, 103.
Colbran, R.J., et al. 1989. J. Biol. Chem. 264, 4800.
Colbran, R.J., et al. 1988. J. Biol. Chem.263, 18145.

法的情報

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全性情報

• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 1
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable