V104

D-(+)-Vesamicol hydrochloride

solid

• 実験式（ヒル表記法）: C₁₇H₂₅NO · HCl
• CAS番号: 112709-60-1
• 分子量: 295.85
• MDL番号: MFCD00069370
• UNSPSCコード: 12352005
• PubChem Substance ID: 57654723
• NACRES: NA.22

特性

• 形状: solid
• 色: white
• 溶解性: DMSO: soluble; ethanol: soluble
• SMILES記法: Cl.O[C@H]1CCCC[C@@H]1N2CCC(CC2)c3ccccc3
• InChI: 1S/C17H25NO.ClH/c19-17-9-5-4-8-16(17)18-12-10-15(11-13-18)14-6-2-1-3-7-14;/h1-3,6-7,15-17,19H,4-5,8-13H2;1H/t16-,17-;/m0./s1
• InChI Key: XJNUHVMJVWOYCW-QJHJCNPRSA-N

詳細

詳細

D-(+)-Vesamicol is a potent inhibitor of acetycholine transport into the synaptic vesicles in cholinergic nerve terminals. It is 25-times less potent than the L-form.

アプリケーション

D-(+)-Vesamicol hydrochloride can be used as a reactant to prepare:

• Trialkylstannyl vesamicol analogs as potent vesicular acetylcholine transporters (VAChTs) and sigma receptors.
• Vesamicol analog, (+)-2-[4-(4-iodophenyl)piperidino] cyclohexanol as a possible tumor imaging agent.

生物化学的／生理学的作用

Less active enantiomer of vesamicol

安全性情報

• ピクトグラム: GHS07
• シグナルワード: Warning
• 危険有害性情報: H302 + H312 + H332
• 注意書き: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312
• 危険有害性の分類: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
• 保管分類コード: 11 - Combustible Solids
• WGK: WGK 3
• 引火点(°F): Not applicable
• 引火点(℃): Not applicable
• 個人用保護具 (PPE): dust mask type N95 (US), Eyeshields, Gloves