177989

クロロギ酸イソブチル

98%

• 別名: IBCF, クロロギ酸イソブチルエステル
• 化学式: ClCO₂CH₂CH(CH₃)₂
• CAS番号: 543-27-1
• 分子量: 136.58
• Beilstein: 956590
• EC Number: 208-840-1
• MDL番号: MFCD00000642
• UNSPSCコード: 12352100
• PubChem Substance ID: 24850706
• NACRES: NA.22

特性

• 蒸気圧: 0.33 mmHg ( 20 °C)
• アッセイ: 98%
• 形状: liquid
• 屈折率: n20/D 1.407 (lit.)
• bp: 128.8 °C (lit.)
• 溶解性: benzene: miscible; chloroform: miscible; diethyl ether: miscible
• 密度: 1.053 g/mL at 25 °C (lit.)
• SMILES記法: CC(C)COC(Cl)=O
• InChI: 1S/C5H9ClO2/c1-4(2)3-8-5(6)7/h4H,3H2,1-2H3
• InChI Key: YOETUEMZNOLGDB-UHFFFAOYSA-N

詳細

詳細

クロロギ酸イソブチル（IBCF）は、ペプチド試薬として使用されます。オリゴヌクレオチド合成で、IBCFはデオキシリボシドの5′-ヒドロキシル機能を遮断します。縮合試薬としても機能します。

アプリケーション

• Preparation of a volatile derivative of taurine and application to gas chromatographic determination of urinary taurine.: Demonstrates the utility of isobutyl chloroformate in preparing volatile derivatives of taurine for gas chromatographic analysis, offering a methodological advancement in clinical biochemistry (Masuoka et al., 1989).
• Quinazoline antifolates inhibiting thymidylate synthase: synthesis of four oligo(L-gamma-glutamyl) conjugates of N10-propargyl-5,8-dideazafolic acid and their enzyme inhibition.: This article investigates the synthesis and biological activity of quinazoline antifolates, using techniques including isobutyl chloroformate, relevant in medicinal chemistry and drug development (Pawelczak et al., 1989).
• Coupling of peptides to protein carriers by mixed anhydride procedure.: Discusses a novel technique using isobutyl chloroformate for peptide coupling to proteins, useful in bioconjugate chemistry and vaccine development (Samokhin & Filimonov, 1985).
• Folate analogues altered in the C9-N10 bridge region. 18. Synthesis and antitumor evaluation of 11-oxahomoaminopterin and related compounds.: Investigates the role of isobutyl chloroformate in synthesizing folate analogues for cancer research, showing its importance in therapeutic chemistry (Nair et al., 1981).

安全性情報

• ピクトグラム: GHS02,GHS06,GHS05
• シグナルワード: Danger
• 危険有害性情報: H226,H302,H314,H330
• 注意書き: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• 危険有害性の分類: Acute Tox. 2 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1B
• 保管分類コード: 3 - Flammable liquids
• WGK: WGK 2
• 引火点(°F): 96.8 °F - closed cup
• 引火点(℃): 36 °C - closed cup
• 個人用保護具 (PPE): Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter