GNE
glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
別名:
DMRV, GLCNE, IBM2, NM, Uae1
Species:
Human GNE (10020), Mouse Gne (50798), Rat Gne (114711), Zebrafish gne (393857), chicken GNE (427285), dog GNE (481607), Horse GNE (100067216), domestic cat GNE (101098411), sheep GNE (101110735), cow GNE (782201) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(10020) Summary: The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(50798) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Rat(114711) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Zebrafish(393857) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- chicken(427285) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- dog(481607) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Horse(100067216) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- domestic cat(101098411) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- sheep(101110735) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- cow(782201) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- Domestic Rabbit(100340455) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- naked mole-rat(101705910) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
- domestic guinea pig(100731383) glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
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Antibodies
製品番号
詳細
交差性
アプリケーション
抗GNE抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
抗GNE抗体 ウサギ宿主抗体, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
immunohistochemistry