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Merck

GCK

glucokinase (hexokinase 4)

別名:
FGQTL3, GK, GLK, HHF3, HK4, HKIV, HXKP, LGLK, MODY2
Species:
UniProtKB ID:
遺伝子ID:
  • Human(2645) Summary: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]
  • Mouse(103988) glucokinase
  • Rat(24385) glucokinase
  • Zebrafish(751668) glucokinase (hexokinase 4, maturity onset diabetes of the young 2)
  • chicken(430370) glucokinase (hexokinase 4)
  • domestic cat(100037406) glucokinase (hexokinase 4)
  • dog(606490) glucokinase (hexokinase 4)
  • sheep(101117412) glucokinase (hexokinase 4)
  • cow(616576) glucokinase (hexokinase 4)
  • Horse(100051836) glucokinase (hexokinase 4)
  • naked mole-rat(101721664) glucokinase (hexokinase 4)
  • domestic guinea pig(100717630) glucokinase (hexokinase 4)

Custom & Knockdown Gene Products

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  • Custom Gene Products

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Antibodies

製品番号
詳細
交差性
アプリケーション
抗GCK抗体 ウサギ宿主抗体, Ab1, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
Anti-Glucokinase/GCK Antibody, clone 9G1.2, clone 9G1.2, from mouse,
交差性
human
アプリケーション
immunohistochemistry
western blot
Anti-Glucokinase (GCK) Antibody, clone 4K9D5, Rabbit Monoclonal, ,
交差性
human, rat
アプリケーション
immunoprecipitation (IP)
western blot
Monoclonal Anti-GCK, (C-terminal) antibody produced in mouse, clone 1G10, purified immunoglobulin, buffered aqueous solution,
交差性
human
アプリケーション
ELISA
western blot
Anti-GCK antibody produced in rabbit, ,
交差性
human, mouse, rat
アプリケーション
immunofluorescence
western blot

Kits

製品番号
詳細
Species
ヘキソキナーゼ比色アッセイキット, sufficient for 100 colorimetric tests,
Species
mouse, rat, human

esiRNA

製品番号
詳細
Species
MISSION® esiRNA, targeting human GCK,
Species
human