ALK
anaplastic lymphoma receptor tyrosine kinase
別名:
CD246, NBLST3
Species:
Human ALK (238), Mouse Alk (11682), Rat Alk (266802), fruit fly Alk (53425), Zebrafish alk (563509), chicken ALK (421297), domestic cat ALK (101091689), dog ALK (483021), Horse ALK (100070891), sheep ALK (101114094) ...詳細
UniProtKB ID:
遺伝子ID:
- Human(238) Summary: This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
- Mouse(11682) anaplastic lymphoma kinase
- Rat(266802) anaplastic lymphoma receptor tyrosine kinase
- fruit fly(53425) CG8250 gene product from transcript CG8250-RB
- Zebrafish(563509) anaplastic lymphoma kinase (Ki-1)
- chicken(421297) anaplastic lymphoma receptor tyrosine kinase
- domestic cat(101091689) anaplastic lymphoma receptor tyrosine kinase
- dog(483021) anaplastic lymphoma receptor tyrosine kinase
- Horse(100070891) anaplastic lymphoma receptor tyrosine kinase
- sheep(101114094) anaplastic lymphoma receptor tyrosine kinase
- domestic guinea pig(100732585) anaplastic lymphoma receptor tyrosine kinase
- naked mole-rat(101703312) anaplastic lymphoma receptor tyrosine kinase
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ELISA
製品番号
詳細
Species
Antibodies
製品番号
詳細
交差性
アプリケーション
Anti-ALK Antibody, clone ALK1, clone ALK1, from mouse,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Anti-phospho-ALK (pTyr1604) antibody produced in rabbit, affinity isolated antibody,
交差性
human, mouse, rat
アプリケーション
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-ALK Antibody, clone 1D13 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
交差性
human, mouse
アプリケーション
ELISA
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-ALK antibody, Rabbit monoclonal, recombinant, expressed in HEK 293 cells, clone RM361, purified immunoglobulin,
交差性
human
アプリケーション
immunohistochemistry
western blot
western blot
Anti-ALK (Phospho-TYR1604), affinity isolated antibody,
交差性
human
アプリケーション
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Small Molecule - Inhibitor
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Species
esiRNA
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Species