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  • Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules.

Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules.

Cell discovery (2015-12-01)
Nathan D Camp, Kyung-Soon Lee, Jennifer L Wacker-Mhyre, Timothy S Kountz, Ji-Min Park, Dorathy-Ann Harris, Marianne Estrada, Aaron Stewart, Alejandro Wolf-Yadlin, Chris Hague
PMID26617989
ABSTRACT

Recent advances in proteomic technology reveal G-protein-coupled receptors (GPCRs) are organized as large, macromolecular protein complexes in cell membranes, adding a new layer of intricacy to GPCR signaling. We previously reported the α