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A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO.

A novel self-assembled sandwich nanomedicine for NIR-responsive release of NO.

Nanoscale (2015-11-17)

Jing Fan, Nongyue He, Qianjun He, Yi Liu, Ying Ma, Xiao Fu, Yijing Liu, Peng Huang, Xiaoyuan Chen

ABSTRACT

A novel sandwich nanomedicine (GO-BNN6) for near-infrared (NIR) light responsive release of nitric oxide (NO) has been constructed by self-assembly of graphene oxide (GO) nanosheets and a NO donor BNN6 through the π-π stacking interaction. The GO-BNN6 nanomedicine has an extraordinarily high drug loading capacity (1.2 mg BNN6 per mg GO), good thermal stability, and high NIR responsiveness. The NO release from GO-BNN6 can be easily triggered and effectively controlled by adjusting the switching, irradiation time and power density of NIR laser. The intracellular NIR-responsive release of NO from the GO-BNN6 nanomedicine causes a remarkable anti-cancer effect.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Ethanol, JIS first grade, 94.8-95.8%

Supelco

Ethanol solution, certified reference material, 2000 μg/mL in methanol

Sigma-Aldrich

Ethanol Fixative 80% v/v, suitable for fixing solution (blood films)

Sigma-Aldrich

Ethanol, JIS special grade, 94.8-95.8%

Sigma-Aldrich

Ethanol, JIS special grade, ≥99.5%

Sigma-Aldrich

Ethanol, ≥99.5%

Sigma-Aldrich

Sodium nitrite, SAJ first grade, ≥97.0%

Sigma-Aldrich

Ethanol, SAJ first grade, ≥99.5%

Sigma-Aldrich

Ethanol, ≥99.5%, suitable for fluorescence

Sigma-Aldrich

Ethanol, JIS 1000, ≥99.5%, for residue analysis

Sigma-Aldrich

Ethanol, JIS 300, ≥99.5%, for residue analysis

Sigma-Aldrich

Ethanol, ≥99.5%, suitable for absorption spectrum analysis

Sigma-Aldrich

Ethanol, ≥99.5%, suitable for HPLC

Sigma-Aldrich

Sodium nitrite, 99.999% trace metals basis

Sigma-Aldrich

Ethyl alcohol, Pure, 190 proof, ACS spectrophotometric grade, 95.0%

Supelco

Ethanol standards 10% (v/v), 10 % (v/v) in H₂O, analytical standard

Sigma-Aldrich

Sodium nitrite, JIS special grade, ≥98.5%

Sigma-Aldrich

Ethanol, ≥99.5%, SAJ super special grade

Sigma-Aldrich

Sodium nitrite, ACS reagent, ≥97.0%

Sigma-Aldrich

Sodium nitrite, anhydrous, Redi-Dri^™, ReagentPlus^®, ≥99.0%

Sigma-Aldrich

Ethanol, purum, fine spirit, denaturated with 4.8% methanol, F25 METHYL¹, ~96% (based on denaturant-free substance)

Sigma-Aldrich

Sodium nitrite, ReagentPlus^®, ≥99.0%

Sigma-Aldrich

Ethanol, puriss. p.a., absolute, ≥99.8% (GC)

Sigma-Aldrich

Sodium nitrite, anhydrous, free-flowing, Redi-Dri^™, ACS reagent, ≥97%

Sigma-Aldrich

Ethyl alcohol, Pure, 200 proof, for molecular biology