- Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.
Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins.
Bioorganic & medicinal chemistry letters (2004-02-26)
Nobuko Sakurai, Jiu-Hong Wu, Yutaka Sashida, Yoshihiro Mimaki, Tamotsu Nikaido, Kazuo Koike, Hideji Itokawa, Kuo-Hsiung Lee
PMID14980692
ABSTRACT
Actein (1), a tetracyclic triterpenoid from the rhizome of Cimicifuga racemosa (black cohosh), and 82 related triterpenoid and steroidal saponins isolated from higher plants were evaluated for anti-HIV activity as a continuing study to discover potential anti-AIDS agents from natural products. Actein showed potent activity and another twelve saponins showed moderate activity. The active compounds included two steroidal, seven tetracyclic triterpenoid, and four pentacyclic triterpenoid compounds.
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