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'One-pot' synthesis of dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a silver(I)-catalyzed cascade approach.

'One-pot' synthesis of dihydrobenzo[4,5][1,3]oxazino[2,3-a] isoquinolines via a silver(I)-catalyzed cascade approach.

Molecules (Basel, Switzerland) (2013-01-25)

Baifeng Jiang, Yu Zhou, Qingya Kong, Hualiang Jiang, Hong Liu, Jian Li

ABSTRACT

An efficient approach for the synthesis of biologically interesting fused tetracyclic isoquinolines in high yields and with a broad substrate scope has been developed. The strategy features an AgNO(3) catalyzed 'one-pot' cascade process involving formation of two new C-N bonds and one new C-O bond.

MATERIALS

Product Number

Brand

Product Description

Sigma-Aldrich

Silver nitrate, tested according to Ph. Eur.

Sigma-Aldrich

Silver nitrate, 99.9999% trace metals basis

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Silver nitrate, SAJ first grade, ≥99.8%

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Silver nitrate, puriss. p.a., ACS reagent, reag. ISO, reag. Ph. Eur., ≥99.8%

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Silver nitrate, meets analytical specification of Ph. Eur., BP, USP, 99.8-100.5%

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Silver nitrate, puriss. p.a., ≥99.5% (AT)

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Sigma-Aldrich

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