InCl3-catalyzed allylic Friedel-Crafts reactions toward the stereocontrolled synthesis of 1,2,3,4-tetrahydroquinolines.

InCl3-catalyzed allylic Friedel-Crafts reactions toward the stereocontrolled synthesis of 1,2,3,4-tetrahydroquinolines.

Organic letters (2010-10-01)

David S Giera, Christoph Schneider

PMID20879793

ABSTRACT

Allyl chlorides tethered to an N-aryl moiety readily undergo InCl(3)-catalyzed Friedel-Crafts reactions to furnish highly enantiomerically enriched 1,2,3,4-tetrahydroquinolines with good yields and excellent diastereoselectivity.

MATERIALS

Product Number

Brand

Product Description

334065

Sigma-Aldrich

Indium(III) chloride, 98%

Pricing and availability is not currently available.

429414

Sigma-Aldrich

Indium(III) chloride, anhydrous, powder, ≥99.999% trace metals basis

Pricing and availability is not currently available.

203440

Sigma-Aldrich

Indium(III) chloride, 99.999% trace metals basis

Pricing and availability is not currently available.