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Key Documents

Safety Information

SRP6590

Sigma-Aldrich

Core Histones human

≥95% (SDS-PAGE)

Synonym(s):

HeLa Core Histones

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

Assay

≥95% (SDS-PAGE)

form

liquid

packaging

pkg of 50 and 100 μg

concentration

1 mg/mL

technique(s)

cell based assay: suitable

shipped in

dry ice

storage temp.

−70°C

General description

A nucleosome is the basic repeating unit of chromatin in which 146 base pairs of DNA wrap twice around a histone octamer consisting of two copies of each of the core histones, H2A, H2B, H3, and H4. The combination of two H2A/H2B dimers and one H3/H4 tetramer create the nucleosome core. Further, histone H1 combines with these histones to form 30nm fibers. These fibers have six nucleosomes per turn in a solenoid arrangement. Histone H3 undergoes many modifications which include acetylation, methylation, and phosphorylation that are important for regulation of gene transcription.

Physical form

50 mM sodium phosphate, pH 6.9, containing 10 mM sodium chloride and 1 mM β-mercaptoethanol.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

PRTR

Class II Designated Chemical Substances

ISHL Indicated Name

Substances Subject to be Indicated Names

ISHL Notified Names

Substances Subject to be Notified Names

JAN Code

SRP6590-50UG:
SRP6590-100UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Transcription regulation by histone methylation: interplay between different covalent modifications of the core histone tails.
Zhang Y and Reinberg D
Genes & Development, 15(18), 2343-2360 (2001)
Roberto Fabian et al.
Molecules (Basel, Switzerland), 26(16) (2021-08-28)
We report data from single molecule studies on the interaction between single DNA molecules and core histones using custom-designed horizontal magnetic tweezers. The DNA-core histone complexes were formed using λ-DNA tethers, core histones, and NAP1 and were exposed to forces

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