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Safety Information

SRP0315

Sigma-Aldrich

JARID1A human

recombinant, expressed in baculovirus infected Sf9 cells, ≥80% (SDS-PAGE)

Synonym(s):

KDM5A, RBP2, lysine (K)-specific demethylase 5A

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About This Item

UNSPSC Code:
12352200
NACRES:
NA.32

biological source

human

recombinant

expressed in baculovirus infected Sf9 cells

Assay

≥80% (SDS-PAGE)

form

aqueous solution

mol wt

125 kDa

packaging

pkg of 20 μg

NCBI accession no.

NM_001042603

UniProt accession no.

P29375

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... KDM5A(5927)

General description

Human JARID1A, also known as KDM5A and RBBP2, (GenBank Accession No. NM_001042603), amino acids 1-1090 with C-terminal FLAG-tag, MW= 125 kDa, expressed in Sf9 cells via a Baculovirus expression system.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

Cartagena Act

Cartagena Act Listed

JAN Code

SRP0315-20UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Laura J C M van Zutven et al.
Genes, chromosomes & cancer, 45(5), 437-446 (2006-01-19)
Chromosome rearrangements are found in many acute leukemias. As a result, genes at the breakpoints can be disrupted, forming fusion genes. One of the genes involved in several chromosome aberrations in hematological malignancies is NUP98 (11p15). As NUP98 is close
Xue Zhou et al.
Cancer research, 70(10), 4214-4221 (2010-04-22)
Histone H3 lysine 4 (H3K4) trimethylation (H3K4me3) at the promoter region of genes has been linked to transcriptional activation. In the present study, we found that hypoxia (1% oxygen) increased H3K4me3 in both normal human bronchial epithelial Beas-2B cells and
Alexander Roesch et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 18(9), 1249-1257 (2005-04-02)
In malignant melanomas, the loss of cell cycle control is thought to be due to a lack of retinoblastoma protein (pRb)-activity. Members of the previously described family of retinoblastoma-binding proteins (RBPs) are supposed to act as pRb-modulating factors. Based on

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