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Safety Information

SML3366

Sigma-Aldrich

SIS17

≥95% (HPLC)

Synonym(s):

N′-Hexadecylthiophene-2-carbohydrazide, SIS 17, SIS-17

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About This Item

Empirical Formula (Hill Notation):
C21H38N2OS
CAS Number:
2374313-54-7
Molecular Weight:
366.60
MDL number:
MFCD32201127
UNSPSC Code:
12352200
NACRES:
NA.77
Pricing and availability is not currently available.

Quality Level

100

Assay

≥95% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear (Warmed)

storage temp.

-10 to -25°C

SMILES string

[s]1c(ccc1)C(=O)NNCCCCCCCCCCCCCCCC

InChI

1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)

InChI key

HSHXDCVZWHOWCS-UHFFFAOYSA-N

Related Categories

Biochem/physiol Actions

Potent and selective HDAC11 inhibitor that effectively upregulates cellular serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level.
SIS17 is a potent and selective HDAC11 inhibitor (IC50 = 830 nM; IC50 >100 μM against HDAC1/4/8 or SIRT1/2/3/6) that effectively upregulates HDAC11 substrate, serine hydroxymethyl transferase 2 (SHMT2), fatty acylation level in MCF7 cells (12.5 μM).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3366-VAR:
SML3366-BULK:
SML3366-50MG:
SML3366-10MG:

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Certificates of Analysis (COA)

Lot/Batch Number
0000194414
0000194413
0000188668
0000194414
0000194413

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