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Safety Information

SML3078

Sigma-Aldrich

JT003 trifluoroacetate

≥95% (HPLC)

Synonym(s):

P-Nva-LYYFA trifluoroacetate

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About This Item

Empirical Formula (Hill Notation):
C46H62N8O9 · xC2HF3O2
Molecular Weight:
871.03 (free base basis)
UNSPSC Code:
51111800
NACRES:
NA.77

Quality Level

100

Assay

≥95% (HPLC)

form

film or powder

color

white to off-white

storage temp.

−20°C

Biochem/physiol Actions

JT003 is potent dual agonist of adiponectin receptors AdipoR1/AdipoR2 that potently improves insulin resistance in high fat diet induced nonalcoholic steatohepatitis (NASH) mice. JT003 inhibits hepatic stellate cells (HSCs) activation in CCl4 induced liver fibrosis.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

SML3078-BULK:
SML3078-5MG:
SML3078-VAR:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Michishige Terasaki et al.
International journal of molecular sciences, 21(13) (2020-07-11)
Dipeptidyl peptidase-4 (DPP-4) inhibitors have been reported to play a protective role against atherosclerosis in both animal models and patients with type 2 diabetes (T2D). However, since T2D is associated with dyslipidemia, hypertension and insulin resistance, part of which are
Hongjiao Xu et al.
Nature communications, 11(1), 5807-5807 (2020-11-18)
Chronic nonalcoholic steatohepatitis (NASH) is a metabolic disorder that often leads to liver fibrosis, a condition with limited therapy options. Adiponectin is an adipocytokine that regulates glucose and lipid metabolism via binding to its receptors AdipoR1 and AdipoR2, and AdipoRs

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