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PZ0389

Sigma-Aldrich

PF-06869206

≥98% (HPLC)

Synonym(s):

(S)-3-Chloro-7-(2-(hydroxymethyl)morpholino)-2-methyl-5-(trifluoromethyl)-1H-pyrrolo[3,2-b]pyridine-6-carbonitrile, PF 06869206, PF06869206

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5 MG
¥14,200
25 MG
¥47,770

¥14,200

Estimated to ship onApril 09, 2025

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5 MG
¥14,200
25 MG
¥47,770

About This Item

Empirical Formula (Hill Notation):
C15H14ClF3N4O2
CAS Number:
2227425-05-8
Molecular Weight:
374.75
UNSPSC Code:
51111800
NACRES:
NA.77

¥14,200

Estimated to ship onApril 09, 2025

Request a Bulk Order

Assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

room temp

SMILES string

ClC1=C(C)NC2=C1N=C(C(F)(F)F)C(C#N)=C2N3C[C@@H](CO)OCC3

InChI

1S/C15H14ClF3N4O2/c1-7-10(16)11-12(21-7)13(23-2-3-25-8(5-23)6-24)9(4-20)14(22-11)15(17,18)19/h8,21,24H,2-3,5-6H2,1H3/t8-/m0/s1

InChI key

ATFQBBCQZKVZJN-QMMMGPOBSA-N

Application

PF-06869206 has been used to selectively inhibit the activity of sodium-phosphate cotransporter 2a (NaPi2a).[1]

Biochem/physiol Actions

PF-06869206 is a selective inhibitor against sodium-phosphate cotransporter 2A (NaPi-2a, NaPi-Iia, Na+/Pi cotransporter 2A, Na+-dependent phosphate cotransporter 2A).
PF-06869206 may be used to treat patients with mineral and hormonal derangements linked with increased cardiovascular risk in chronic kidney disease. This drug might also improve urinary phosphate excretion.[2] PF-06869206 has an ability to decrease phosphate uptake in human embryonic kidney (HEK) cells transfected with mouse or rat renal sodium-dependent phosphate transporter genes (Npt2a).[3]

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

PDSCL

Deleterious substance

JAN Code

PZ0389-5MG:4548173357270
PZ0389-BULK:
PZ0389-25MG:4548173357263
PZ0389-VAR:

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Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1)
Filipski KJ, et al.
ACS Medicinal Chemistry Letters, 9(5), 440-445 (2018)
Synthesis of PF-06869206
Kocienski P
Synfacts, 14(07), 0675-0675 (2018)
In vivo effects of renal Npt2a inhibition
Thomas L, et al.
Faseb Journal, 33(1-supplement), 751-752 (2019)

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