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Safety Information

P3136

Sigma-Aldrich

Polydeoxyguanylic acid · Polydeoxycytidylic acid sodium salt

double-stranded homopolymer

Synonym(s):

Poly(dG) • Poly(dC)

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About This Item

CAS Number:
119039-74-6
MDL number:
MFCD00131969
UNSPSC Code:
41106305
NACRES:
NA.51

form

solid

storage temp.

−20°C

Application

Polydeoxyguanylic acid • Polydeoxycytidylic acid (Poly(dG) • Poly(dC)) is a high molecular weight double-stranded homopolymer DNA model compound used for conformational studies of DNA structure dynamics and drug and small molecule interactions.

Other Notes

High molecular weight double-stranded homopolymer

Unit Definition

One unit will yield an A260 of 1.0 in 1.0 ml of 20 mM sodium phosphate/100 mM NaCl, pH 7.0 (1 cm light path).

Reconstitution

Polymers composed of dG and dC can be difficult to dissolve. The recommended dissolution method for poly(dG) • poly(dC) is to suspend the polymer in a minimum of 15 μl per unit in water or buffer and heat to 50-55 °C for 30 minutes with occasional mixing by inversion.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

P3136-10UN-PW:
P3136-100UN:
P3136-10UN:
P3136-25UN-PW:
P3136-VAR:
P3136-25UN:
P3136-BULK:

Certificates of Analysis (COA)

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Studies of the fluorescence light-up effect of amino-substituted benzo[b]quinolizinium derivatives in the presence of biomacromolecules.
Faulhaber K, Granzhan A, Ihmels H, et al.
Photochemistry and Photobiology, 10, 1535-1545 (2011)
Sebastiano Campagna et al.
Inorganic chemistry, 50(21), 10667-10672 (2011-10-01)
Efficient intercalation of a luminescent Ir(III) complex exclusively made of polypyridine ligands in natural and synthetic biopolymers is reported for the first time. The emission of the complex is largely enhanced in the presence of [poly(dA-dT)(2)] and strongly quenched in
M Behe et al.
Proceedings of the National Academy of Sciences of the United States of America, 78(3), 1619-1623 (1981-03-01)
We have compared the behavior in solution of the synthetic polynucleotide poly(dG-m5dC).poly(dG-m5dC) with that of the unmethylated polynucleotide poly(dG-dC).poly(dG-dC). In solutions containing high concentrations of salt, poly(dG-dC).poly(dG-dC) is known to exhibit altered circular dichroic and absorption spectra correlated with formation
Marta Airoldi et al.
Journal of biomolecular structure & dynamics, 23(4), 465-478 (2005-12-21)
The model polynucleotide poly(dG-dC).poly(dG-dC) (polyGC) was titrated with a strong acid (HCl) in aqueous unbuffered solutions and in the quaternary w/o microemulsion CTAB/n-pentanol/n-hexane/water. The titrations, performed at several concentrations of NaCl in the range 0.005 to 0.600 M, were followed
Marta Airoldi et al.
Journal of biomolecular structure & dynamics, 29(3), 585-594 (2011-11-10)
When the model polynucleotide poly(dG-dC)∙poly(dG-dC) [polyGC] is titrated with a strong acid (HCl) in unbuffered aqueous solutions containing the chlorides of the alkali metals in the concentration range 0.010 M-0.600 M, two transitions in the absorbance vs. pH plots are evidenced, characterized

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