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D6148

Sigma-Aldrich

Diethylenetriaminepentaacetic acid dianhydride

Synonym(s):

DTPA anhydride, DTPA dianhydride

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About This Item

Empirical Formula (Hill Notation):
C14H19N3O8
CAS Number:
Molecular Weight:
357.32
Beilstein:
1230954
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:

storage temp.

−20°C

SMILES string

OC(=O)CN(CCN1CC(=O)OC(=O)C1)CCN2CC(=O)OC(=O)C2

InChI

1S/C14H19N3O8/c18-10(19)5-15(1-3-16-6-11(20)24-12(21)7-16)2-4-17-8-13(22)25-14(23)9-17/h1-9H2,(H,18,19)

InChI key

RAZLJUXJEOEYAM-UHFFFAOYSA-N

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Application

Reagent for introducing a strong chelator onto proteins.

replaced by

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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Statements

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

D6148-5G:
D6148-1G:
D6148-10G:
D6148-25G:
D6148-BULK:


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T S Wang et al.
Nuklearmedizin. Nuclear medicine, 23(4), 193-195 (1984-08-01)
The cyclic anhydride (CA) and the mixed anhydride (MA) of DTPA were synthesized and used to chelate 111In to an antimelanoma monoclonal antibody. The CA and MA methods showed mean labeling efficiencies of 25.7 and 20.5%, respectively (p = NS).
Chad R Haney et al.
Biochimica et biophysica acta, 1725(3), 358-369 (2005-08-17)
The purpose of this study was to prepare a novel polymerized hemoglobin (Hb) based oxygen carrier (HBOC) designed to minimize Hb induced hypertension, while employing a simple and inexpensive method of preparation. Cyclic-diethylenetriaminepentaacetic acid (DTPA) was used to polymerize stroma
C H Paik et al.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 24(12), 1158-1163 (1983-12-01)
Diethylenetriaminepentaacetic acid (DTPA) was conjugated with a practical concentration (300 micrograms/ml) of antibody to human albumin (Ab) and 1083 17-1A monoclonal colorectal antibody (MAb-17-1A) via an acylation reaction using cyclic DTPA anhydride (cDTPAA). The conjugation reaction was favored as pH
M Perälä et al.
European journal of nuclear medicine, 16(8-10), 621-626 (1990-01-01)
In this study we examined optimization of derivatization of monoclonal antibodies and their fragments intended for use as radiopharmaceutical in radioimaging and/or radioimmunotherapy of prostatic cancer. Two different principles were used to conjugate diethylenetriaminepentaacetic acid (DTPA) to a monoclonal antibody
M Hartikka et al.
European journal of nuclear medicine, 15(3), 157-161 (1989-01-01)
F(ab')2 fragments (at concentrations of 5-30 mg/ml) derived from monoclonal antibodies raised against human prostate specific acid phosphatase were derivatized with a bicyclic anhydride of diethylenetriaminepentaacetic acid (cDTPAA) in the molar ratios of cDTPAA/F(ab')2 of 1:1, 5:1, 10:1 or 50:1.

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