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B3811

Sigma-Aldrich

B-9430 trifluoroacetate salt

≥98% (HPLC)

Synonym(s):

D-Arg-Arg-Pro-Hyp-Gly-Igl-Ser-D-Igl-Oic-Arg trifluoroacetate salt, D-Arg-[Hyp3, Igl5, D-Igl7, Oic8]-Bradykinin trifluoroacetate salt

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About This Item

Empirical Formula (Hill Notation):
C64H95N19O13 · xC2HF3O2
CAS Number:
180981-09-3
Molecular Weight:
1338.56 (free base basis)
UNSPSC Code:
12352200

Assay

≥98% (HPLC)

form

solid

storage condition

protect from light
under inert gas

solubility

H2O: ≥2 mg/mL

shipped in

wet ice

storage temp.

−20°C

Amino Acid Sequence

Arg-Arg-Pro-Hyp-Gly-Igl-Ser-Igl-Oic-Arg

Biochem/physiol Actions

B-9430 was developed by Gera at the Stewart laboratory1 and is a stable, potent, and long lasting Bradykinin (BK) antagonist, a candidate anti-inflammatory drug. B-9430 shows potency at bradykinin B2 (pA2 = 8.6) and B1 receptors (pA2 = 7.3). Bradykinin is an important growth factor for small-cell lung cancer (SCLC) and prostate cancer (PC). BK receptors are expressed on almost all lung cancer cell lines and on many PC cells. B-9430 is very resistant to kinases and thus shows a very long action in vivo. This peptide is unique among bradykinin antagonists in that it is active after oral administration.

Caution

Product is air and light sensitive. Store in the dark.

Storage Class Code

13 - Non Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

B3811-1MG:
B3811-VAR:
B3811-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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