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A4475

Sigma-Aldrich

Anti-Annexin VII antibody, Mouse monoclonal

clone 203-217/6, purified from hybridoma cell culture

Synonym(s):

Synexin

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About This Item

MDL number:
MFCD03792412
UNSPSC Code:
12352203
NACRES:
NA.44

biological source

mouse

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

203-217/6, monoclonal

form

buffered aqueous solution

mol wt

antigen 47-51 kDa

species reactivity

mouse, canine, rat, chicken, bovine, human, rabbit

technique(s)

immunocytochemistry: suitable using methanol or 1% paraformaldehyde/0.1% glutaraldehyde
immunohistochemistry (frozen sections): suitable
microarray: suitable
western blot: 0.5-1 μg/mL using whole cell extract of culture mouse connective tissue (A9) cells.

isotype

IgG1

UniProt accession no.

P20073

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ANXA7(310)
mouse ... Anxa7(11750)
rat ... Anxa7(155423)

Related Categories

General description

Annexin VII (synexin) is a membrane binding protein that localizes in the nucleus and cytosol. In humans and mice, Annexin VII is encoded by a single gene that has alternatively spliced cassette exons. As a result, two isoforms of molecular mass of 47kDa and 51kDa are expressed. These isoforms differ in their N-terminal region and also have distinct tissue-specific expression patterns.
Anti-Annexin VII antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the 203-217/6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant mouse Annexin VII. The human annexin VII (ANXA7) is located on chromosome 10q21.

Specificity

Mouse monoclonal anti-annexin VII antibody reacts with human, bovine, rabbit, dog, rat, mouse, and chicken Annexin VII.

Immunogen

recombinant mouse annexin VII.

Application

Anti-Annexin VII antibody, Mouse monoclonal has been used in:
  • western blotting
  • immunocytochemistry
  • immunohistochemistry

Biochem/physiol Actions

Antibodies reacting specifically with Annexin VII serve as an essential tool for the detection of this molecule in various cells. The human annexin VII (ANXA7) possesses a tumor suppressor role in prostate cancer. Hence it can be used an important biomarker along with syndecan-1 to predict the survival rates in prostate cancer patients.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

A4475-BULK:
A4475-VAR:
A4475-.2ML:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Tissue microarray analysis delineate potential prognostic role of Annexin A7 in prostate cancer progression
Leighton X, et al.
Testing, 13(10), e0205837-e0205837 (2018)
Annexin A7 suppresses lymph node metastasis of hepatocarcinoma cells in a mouse model
Jin Y, et al.
BMC Cancer, 13(1), 522-522 (2013)
Yanling Jin et al.
BMC cancer, 13, 522-522 (2013-11-06)
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death in China. This study investigated the effects of Annexin A7 (ANXA7) on the inhibition of HCC lymph node metastasis in a mouse model. The stable knockup and knockdown
C S Clemen et al.
Journal of muscle research and cell motility, 20(7), 669-679 (2000-02-15)
Annexin VII exists in a 47 kDa and a 51 kDa isoform with the 51 kDa protein being the only isoform present in skeletal muscle. Expression of the 51 kDa isoform during myogenesis and localization was studied in cells after
ShuYan Liu et al.
Cancer letters, 416, 11-23 (2017-12-17)
Annexin A7 (ANXA7) is a suppressor of tumorigenesis and metastasis in prostate cancer. Activated ANXA7 GTPase promotes prostate cancer cell apoptosis. However, the role and underlying mechanism of ANXA7 GTPase in prostate cancer metastasis have not been established. RKIP is

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