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15450

Sigma-Aldrich

Boc-Leu-OH hydrate

≥99.0% (HPLC)

Synonym(s):

Boc-L-leucine

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About This Item

Linear Formula:
(CH3)2CHCH2CH(COOH)NHCOOC(CH3)3 xH2O
Molecular Weight:
231.29 (anhydrous basis)
EC Number:
236-073-2
MDL number:
MFCD00066067
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
329750886
NACRES:
NA.22

Quality Level

200

Assay

≥99.0% (HPLC)

form

solid

optical activity

[α]20/D −25±0.5°, c = 2% in acetic acid

reaction suitability

reaction type: Boc solid-phase peptide synthesis
reaction type: C-H Activation
reagent type: ligand
reaction type: Peptide Synthesis

mp

85-90 °C

application(s)

peptide synthesis

functional group

amine
carboxylic acid

SMILES string

CC(C)C[C@H](NC(OC(C)(C)C)=O)C(O)=O

Application

Boc-Leu-OH (Boc-L-leucine) was used in the synthesis of a potent cytotoxin, PM-94128.
Boc-protected leucine (Boc-Leu-OH) can be used to generate combinatorial peptide libraries and also to synthesize peptide models to study structure-activity relationships.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

15450-25G-F:
15450-100G-F:
15450-VAR-F:
15450-BULK-F:
15450-5G-F:

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM2163
BCCK5745
BCCJ3943
BCCJ0221
BCCH3198

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Multicyclic polypeptide model compounds. 1. Synthesis of a tricyclic amphiphilic. alpha.-helical peptide using an oxime resin, segment-condensation approach.
Osapay G, et al.
Journal of the American Chemical Society, 112(16), 6046-6051 (1990)
Screening of mixture combinatorial libraries for chiral selectors: a reciprocal chromatographic approach using enantiomeric libraries.
Wu Y, et al.
Analytical Chemistry, 71(9), 1688-1691 (1999)
Masaru Enomoto et al.
The Journal of organic chemistry, 74(19), 7566-7569 (2009-09-03)
The enantioselective total synthesis of PM-94128, a potent cytotoxin of microbial origin, was accomplished by a concise nine-step sequence of reactions in 14% overall yield from N-Boc-l-leucine. The synthesis of Y-05460M-A, a one-carbon lower homologue of PM-94128, was also achieved
The synthesis and screening of a combinatorial peptide library for affinity ligands for glycosylated haemoglobin1.
Chen B, et al.
Biosensors And Bioelectronics, 13(7-8), 779-785 (1998)
Hyun-Woong Cho et al.
PloS one, 14(6), e0217745-e0217745 (2019-06-21)
The aim of this study was to investigate the short-term efficacy and safety of Poly-gamma-glutamic acid (γ-PGA) and the immunologic changes in patients with CIN 1. Participants were randomly assigned to one of two groups and orally treated with placebo
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