SCC101

MCF-7/TAMR-1 Human Breast Cancer Cell Line

Human

• Synonym(s): MCF7 TAMR-1 ; ; Human breast cancer cell line ; ; Tamoxifen resistant breast cancer cell line, MCF7 TAMR-1 Human breast cancer cell line Tamoxifen resistant breast cancer cell line
• UNSPSC Code: 41106514
• eCl@ss: 32011203
• NACRES: NA.81

Properties

• product name: MCF-7/TAMR-1 Human Breast Cancer Cell Line, MCF-7/TAMR-1 is a tamoxifen-resistant cell line derived from the MCF-7/S0.5 human breast cancer cell line by long term treatment with the drug tamoxifen.
• biological source: human
• Quality Level: 100
• technique(s): cell culture | mammalian: suitable
• shipped in: ambient

Description

General description

Estrogen receptor-positive breast cancer is the most common type of breast cancer. About 80% of all breast cancers express the estrogen receptor (ER+) and depend on estrogen to support the growth and spread of the cancer cells. Hormonal therapy, such as tamoxifen, may help slow or stop the growth of ER+ breast cancers by blocking the actions of estrogen. Primary or acquired tamoxifen resistance poses a major clinical challenge in the treatment of ER+ breast cancer. The MCF-7/TAMR-1 cell line provides a model cell system for studying tamoxifen resistance, elucidating signaling pathways involved in tamoxifen-resistant growth, and identifying new predictive markers for response to hormonal therapy.

MCF-7/TAMR-1 is a tamoxifen-resistant cell line derived from the MCF-7/SO.5 cell line that has been adapted to grow at low serum concentration under the long-term treatment with 1 M with tamoxifen. MCF-7/TAMR-1 cells should be maintained in 1 M tamoxifen and may be compared with the parental MCF-7/S0.5 cells, which are sensitive to tamoxifen.

Cell Line Description

Cancer Cells

Application

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.

Quality

• Each vial contains ≥ 1X10⁶ viable cells.
• Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
• Cells are negative for mycoplasma contamination.
• Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.

Storage and Stability

MCF-7/TAMR-1 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point(F): 188.6 °F - closed cup - (Dimethylsulfoxide)
• Flash Point(C): 87 °C - closed cup - (Dimethylsulfoxide)