ECM435

Integrin Classics Kit

• UNSPSC Code: 12161503
• eCl@ss: 32161000
• NACRES: NA.41

Properties

• species reactivity: human
• Quality Level: 100
• manufacturer/tradename: Chemicon^®
• technique(s): activity assay: suitable; flow cytometry: suitable; immunohistochemistry: suitable; immunoprecipitation (IP): suitable

Description

General description

Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators intimately involved with this expanding field of study. The Integrin Classics Investigator Kit contains several of Chemicon′s most popular integrin antibodies, and allows an initial screenings with small quantities of these antibodies. All antibodies in the Integrin Classics kit are available for purchase individually in larger sizes.

Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.

Chemicon offers the Integrin Classics Investigator Kit for initial screenings for several well-studied integrins. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator.

Application

Research Category
Cell Structure

Research Sub Category
Integrins

Components

alphaV Mouse Monoclonal Antibody (Part No. MAB1953Z-20) - 1 tube, 20 μg.
beta1 Mouse Monoclonal Antibody (Part No. MAB1951Z-20)- 1 tube, 20 μg.
beta2 Mouse Monoclonal Antibody (Part No. MAB1962Z-20) - 1 tube, 20 μg.
alpha5beta1 Mouse Monoclonal Antibody (Part No. MAB1999-20) - 1 tube, 20 μg.
alphaVbeta3 Mouse Monoclonal Antibody (Part No. MAB 1976Z-20) -1 tube, 20 μg.
alphaVbeta5 Mouse Monoclonal Antibody (Part No. MAB1961Z-20)- 1 tube, 20 μg.

Physical form

This kit contains some of Chemicon′s most popular monoclonals to alphaV, beta1, beta2, alphaVbeta3, alpha5beta1, and alphaVbeta5. 20μg each.

Storage and Stability

Store antibodies at -20°C.

Important Note: Due to the small volumes contained within the kit, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid entrapped i

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Safety Information

• Storage Class Code: 12 - Non Combustible Liquids