Skip to Content
Merck
All Photos(2)

Documents

Safety Information

ABE74

Sigma-Aldrich

Anti-FoxP4 Antibody

serum, from rabbit

Synonym(s):

forkhead box P4, fork head-related protein like A, Fork head-related protein-like A, winged-helix repressor FOXP4

Sign Into View Organizational & Contract Pricing
All Photos(2)

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

species reactivity (predicted by homology)

mouse (based on 100% sequence homology)

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

NP_001104294

UniProt accession no.

Q9DBY0

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

mouse ... Foxp4(74123)

General description

Forkhead box protein P4 (FoxP4) is a multidomain transcriptional repressor. This protein is a member of the Fox family of proteins characterized by it unique winged-helix DNA binding motif. Members of this family are known for their ability to regulate both the cell fate and differentiation of several tissues. FoxP4 acts to repress expression by inteacting with DNA. For DNA binding to occur, FoxP4 must form homodimers and heterodimers with FoxP1 and FoxP2. During embryogenesis, expression of this protein is observed in lung and brain. In adults expression is observed in adult heart, lung, brain, liver, spleen, testis and kidney. Alternative splicing result in the expression of three known isoforms.

Specificity

This antibody recognizes FoxP4.

Immunogen

Epitope: Unknown
GST-tagged recombinant protein corresponding to mouse FoxP4.

Application

Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected FoxP4 in HeLa cells.

Immunohistochemistry Analysis: A representative lot was used by an independent laboratory in IH. (Lu, M.M., et al. (2002). Mechanisms of Development 119S:S197–S202.)
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Transcription Factors
Use Anti-FoxP4 Antibody (Rabbit Polyclonal Antibody) validated in ICC, WB, IHC to detect FoxP4 also known as forkhead box P4, winged-helix repressor FOXP4.

Quality

Evaluated by Western Blot in human brain cell lysate.

Western Blot Analysis: 1:1,000 dilution of this antibody detected FoxP4 on 10 µg of human brain cell lysate.

Target description

86 and 79 kDa Observed. Three known isoforms due to alternative splicing.

Physical form

Unpurified
Unpurified rabbit polyclonal serum with 0.05% sodium azide.

Storage and Stability

Stable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Analysis Note

Control
Human brain cell lysate

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

ABE74:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Fuhua Wang et al.
Development (Cambridge, England), 149(7) (2022-03-18)
Beige adipocytes have a discrete developmental origin and possess notable plasticity in their thermogenic capacity in response to various environmental cues, but the transcriptional machinery controlling beige adipocyte development and thermogenesis remains largely unknown. By analyzing beige adipocyte-specific knockout mice
Haixia Zhao et al.
Developmental biology, 398(2), 242-254 (2014-12-21)
Osteoblast induction and differentiation in developing long bones is dynamically controlled by the opposing action of transcriptional activators and repressors. In contrast to the long list of activators that have been discovered over past decades, the network of repressors is
Caroline Alayne Pearson et al.
Cell reports, 30(6), 1964-1981 (2020-02-13)
The laminar architecture of the mammalian neocortex depends on the orderly generation of distinct neuronal subtypes by apical radial glia (aRG) during embryogenesis. Here, we identify critical roles for the autism risk gene Foxp1 in maintaining aRG identity and gating

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service