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537011

Sigma-Aldrich

Prolyl Endopeptidase Inhibitor II

The Prolyl Endopeptidase Inhibitor II, also referenced under CAS 108708-25-4, controls the biological activity of Prolyl Endopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Prolyl Endopeptidase Inhibitor II, Z-PP-CHO

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About This Item

Empirical Formula (Hill Notation):
C18H22N2O4
CAS Number:
108708-25-4
Molecular Weight:
330.38
UNSPSC Code:
12352200

Quality Level

100

Assay

≥97% (HPLC)

form

oil

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

colorless to off-white

solubility

DMSO: 10 mg/mL
DMF: soluble
ethyl acetate: soluble

shipped in

ambient

storage temp.

−20°C

General description

A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively). Reported to form a hemiacetal with the active-site serine.
A cell-permeable dipeptide aldehyde that acts as a specific, potent, slow, and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain, respectively). Reported to form a hemiacetal with the active site serine of the enzyme.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
Mouse brain prolylendooeotidase
Product does not compete with ATP.
Reversible: no
Target Ki: 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

Z-Pro-Pro-CHO

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Fülöp, V., et al. 1998. Cell94, 161.
Kahyaoglu, A., et al. 1997. Biochem. J.322, 839.
Bakker, A.V., et al. 1990. Biochem. J.271, 559.
Wilk, S., and Orlowski, M. 1983. J. Neurochem.41, 69.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

537011-MG:
537011-5MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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