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526521

Sigma-Aldrich

PIM1 Inhibitor III

The PIM1 Inhibitor III controls the biological activity of PIM1. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Synonym(s):

PIM1 Inhibitor III

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About This Item

Empirical Formula (Hill Notation):
C28H23N5O5Ru
Molecular Weight:
610.58
UNSPSC Code:
12352200

Quality Level

100

Assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

purple

solubility

DMSO: 6 mg/mL

shipped in

wet ice

storage temp.

−20°C

General description

The racemic mixture of a pyridocarbazolo-cyclopentadienyl Ruthenium complex that acts as a ATP-binding site-targeting, reversible, and highly potent inhibitor of PIM-1 (IC50 = 0.5 and 3 nM for the (S)- and (R)-enantiomer, respectively) with ∼10-fold selectivity over GSK-3α (IC50 = 15 and 20 nM for the (S)- and (R)-enantiomer, respectively).

Biochem/physiol Actions

Cell permeable: no
Primary Target
PIM1
Product does not compete with ATP.
Reversible: no
Target IC50: 0.5 and 3 nM for the (S)- and (R)-enantiomer, of PIM-1, respectively

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Other Notes

Bergman, H. and Meggers, E., 2006. Org. Lett.8, 5465.

Legal Information

Sold for research purposes only, pursuant to an agreement with University of Pennsylvania.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

526521-MG:
526521-1MG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Howard Bregman et al.
Organic letters, 8(24), 5465-5468 (2006-11-17)
Cyclopentadienyl half-sandwich ruthenium complexes have been demonstrated to be promising scaffolds as protein kinase inhibitors. In order to rapidly identify derivatives which display modified pharmacological properties, we developed the synthesis of an organoruthenium compound bearing an N-succinimidyl ester at the
Zhongde Ye et al.
NPJ aging and mechanisms of disease, 7(1), 4-4 (2021-02-10)
MicroRNAs play an important role in the regulation of T cell development, activation, and differentiation. One of the most abundant microRNAs in lymphocytes is miR-181a, which controls T cell receptor (TCR) activation thresholds in thymic selection as well as in

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