Skip to Content
Merck
All Photos(1)

Documents

Safety Information

06-807

Sigma-Aldrich

Anti-LAT Antibody

Upstate®, from rabbit

Synonym(s):

Anti-IMD52, Anti-pp36

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG

NCBI accession no.

NM_014387

UniProt accession no.

O43561

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... LAT(27040)
mouse ... Lat(16797)

Specificity

Recognizes both forms of LAT.

Immunogen

GST-tagged fusion protein corresponding to residues 31-233 of human LAT

Application

Anti-LAT Antibody detects level of LAT & has been published & validated for use in IP & WB.
Research Category
Inflammation & Immunology
Research Sub Category
Immunoglobulins & Immunology

Quality

routinely evaluated by immunoblot on RIPA lysates from Jurkat cells

Target description

36/38 kDa

Physical form

Format: Purified
Protein A Purified immunoglobulin in 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, and 0.05% sodium azide.
Protein A purified

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

Analysis Note

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Not finding the right product?  

Try our Product Selector Tool.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

06-807:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.
Wange, R L, et al.
The Journal of Biological Chemistry, 270, 18730-18733 (1995)
B S Wilson et al.
The Journal of cell biology, 154(3), 645-658 (2001-08-08)
In mast cells, cross-linking the high-affinity IgE receptor (Fc(epsilon)RI) initiates the Lyn-mediated phosphorylation of receptor ITAMs, forming phospho-ITAM binding sites for Syk. Previous immunogold labeling of membrane sheets showed that resting Fc(epsilon)RI colocalize loosely with Lyn, whereas cross-linked Fc(epsilon)RI redistribute
T cell receptor zeta reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor alpha.
Clark, JM; Annenkov, AE; Panesar, M; Isomaki, P; Chernajovsky, Y; Cope, AP
Proceedings of the National Academy of Sciences of the USA null
T Harder et al.
The Journal of cell biology, 151(2), 199-208 (2000-10-19)
Activation of T cell antigen receptor (TCR) induces tyrosine phosphorylations that mediate the assembly of signaling protein complexes. Moreover, cholesterol-sphingolipid raft membrane domains have been implicated to play a role in TCR signal transduction. Here, we studied the assembly of
Displacement of linker for activation of T cells from the plasma membrane due to redox balance alterations results in hyporesponsiveness of synovial fluid T lymphocytes in rheumatoid arthritis.
S I Gringhuis, A Leow, E A Papendrecht-Van Der Voort, P H Remans, F C Breedveld, C L Verweij
Journal of immunology (Baltimore, Md. : 1950) (1950)
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service