Skip to Content
Merck
All Photos(1)

Documents

Safety Information

N-005

Supelco

Norcodeine solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C17H19NO3
CAS Number:
467-15-2
Molecular Weight:
285.34
EC Number:
200-659-6
MDL number:
MFCD00069317
UNSPSC Code:
41116107
PubChem Substance ID:
329818393
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

forensics and toxicology

format

single component solution

storage temp.

−20°C

SMILES string

COc1ccc2C[C@H]3NCC[C@@]45[C@@H](Oc1c24)[C@@H](O)C=C[C@@H]35

InChI

1S/C17H19NO3/c1-20-13-5-2-9-8-11-10-3-4-12(19)16-17(10,6-7-18-11)14(9)15(13)21-16/h2-5,10-12,16,18-19H,6-8H2,1H3/t10-,11+,12-,16-,17-/m0/s1

InChI key

HKOIXWVRNLGFOR-KOFBORESSA-N

General description

Norcodeine is a primary urinary metabolite of codeine. Codeine is an opiate used for its analgesic, antitussive, and sedative properties and is the second-most predominant alkaloid in opium. This certified Snap-N-Spike® Solution is applicable for use in LC/MS or GC/MS applications from urine drug testing and pain prescription monitoring to clinical toxicology and forensic analysis.

Application

  • Pharmacokinetics and nociceptive effects of codeine in horses: A study conducted by Knych HK et al., investigated the pharmacokinetics and the effects on thermal nociception in horses following the administration of codeine. This research provides valuable data for understanding how opioid metabolites like norcodeine behave in non-human subjects, aiding in veterinary pharmacological applications (Knych et al., 2022).
  • Opioid metabolite analysis in forensic toxicology: Jakobsson G and colleagues developed a method using LC-MS/MS to analyze heroin-related compounds, including norcodeine, in postmortem samples. This research is crucial for forensic investigations, providing detailed insights into the metabolite profiles that can assist in the detection and analysis of opioid abuse cases (Jakobsson et al., 2021).
  • Analysis of opioid metabolites in forensic cases: Feliu C et al. presented a technique for quantifying various opioids and their derivatives, such as norcodeine, in whole blood using liquid chromatography-high-resolution mass spectrometry. This method is significant for forensic science, contributing to the accurate assessment of substances involved in fatal cases (Feliu et al., 2020).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Product No.
Description
Pricing

C-006

Codeine solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

A-053

6-Acetylcodeine solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material, Cerilliant®

C-005

Codeine-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-007

Codeine-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-015

Codeine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-040

Codeine-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

C-041

Codeine-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

P-071

Pain Management Multi-component Opiate Mixture-13 solution, 100 μg/mL each component (10 μg/mL Fentanyl), ampule of 1.0 mL, certified reference material, Cerilliant®

O-020

Opiate Multi-component Mixture-5 solution, 250 μg/mL each component in methanol, ampule of 1.0 mL, certified reference material, Cerilliant®

C-087

Codeine-6-β-D-glucuronide solution, 100 μg/mL in methanol: water (2:8), ampule of 1 mL, certified reference material, Cerilliant®

D-019

Dihydrocodeine hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

D-021

Dihydrocodeine-D6 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

D-087

Dihydrocodeine-D6 hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

49.5 °F - closed cup

Flash Point(C)

9.7 °C - closed cup

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

N-005-1ML:
N-005-CC:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

J O Svensson et al.
Journal of chromatography. B, Biomedical applications, 674(1), 49-55 (1995-12-01)
A reversed-phase ion-pair high-performance liquid chromatographic method for the simultaneous determination of codeine and seven metabolites is described. The samples are purified by reversed-phase solid-phase extraction. Codeine, norcodeine, codeine-6-glucuronide, norcodeine-6-glucuronide and morphine-3-glucuronide are measured with UV detection. Detection limits are
Z R Chen et al.
Journal of chromatography, 491(2), 367-378 (1989-07-21)
A novel high-performance liquid chromatographic method for the determination of codeine, norcodeine and morphine in plasma and urine has been developed. The compounds were separated on a cyano column (15 cm x 4.6 mm, 5 microns particle size) using a
[Morphinan alkaloids present in mammal].
Y M Ning et al.
Sheng li ke xue jin zhan [Progress in physiology], 21(4), 329-332 (1990-10-01)
A Somogyi et al.
European journal of clinical pharmacology, 41(4), 379-382 (1991-01-01)
Plasma and urine concentrations of codeine and its measurable metabolites were determined by HPLC in six healthy subjects after a single 30 mg oral dose of codeine either alone or after 7 doses of 1 g paracetamol 8 hourly. After
C L O'Neal et al.
Forensic science international, 95(1), 1-10 (1998-08-27)
Acetylcodeine (AC), an impurity of illicit heroin synthesis, was investigated as a urinary biomarker for detection of illicit heroin use. One hundred criminal justice urine specimens that had been confirmed positive by GC/MS for morphine at concentrations > 5000 ng/ml
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service