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850181P

Avanti

08:0 PI

1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol) (ammonium salt), powder

Synonym(s):

PI(8:0/8:0)

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About This Item

Empirical Formula (Hill Notation):
C25H50NO13P
CAS Number:
2260795-76-2
Molecular Weight:
603.64
UNSPSC Code:
51191904
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 100 μg (with stopper and crimp cap (850181P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (850181P-500ug))

manufacturer/tradename

Avanti Research™ - A Croda Brand 850181P

lipid type

phospholipids
cardiolipins

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](O)[C@H]1O)=O)(OC(CCCCCCC)=O)COC(CCCCCCC)=O.[NH4+]

General description

Phosphatidylinositol (PI), a glycerophospholipid has a head group which carries a cyclohexanol moiety. 08:0 PI (1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol)) is a PI analog with a shorter acyl chain.

Application

08:0 PI (1,2-dioctanoyl-sn-glycero-3-phospho-(1′-myo-inositol)) may be used:
  • as a substrate for phosphatidyl-myo-inositol mannosyltransferase (PimA) to compare the effect of non-substrate phospholipids on the activity
  • as a replacement for mycobacterial membranes in enzymatic assays to measure PimA activity
  • as a phospholipid (PL) standard in the ion trap-time of flight (IT-TOF) system to study the fragmentation principles of unique PLs and also used as a nonendogenous PL standard for the quantitative analysis of PLs in nut samples

Biochem/physiol Actions

Inositol phospholipid species are membrane-bound signaling molecules that have been implicated in almost all aspects of cellular physiology, including cellular growth, metabolism, proliferation, and survival.
Phosphatidylinositol (PI) serves as a precursor of a phosphoinositides, a class of signaling lipids.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (850181P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (850181P-500ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Flash Point(F)

No data available

Flash Point(C)

No data available

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

850181P-VAR:
850181P-BULK:
850181P-500UG:
850181P-100UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Inhibition of Phosphoinositide 3-Kinase and Acquired Long QT Syndrome
Cardiac Electrophysiology: From Cell to Bedside, 106-112 (2018)
Marcelo E Guerin et al.
The Journal of biological chemistry, 282(28), 20705-20714 (2007-05-19)
Mycobacterial phosphatidylinositol mannosides (PIMs) and metabolically derived cell wall lipoglycans play important roles in host-pathogen interactions, but their biosynthetic pathways are poorly understood. Here we focus on Mycobacterium smegmatis PimA, an essential enzyme responsible for the initial mannosylation of phosphatidylinositol.
Endocytosis and the Endosomal Membrane System
Cell Biology, 377-392 (2017)
Shuang Song et al.
Food chemistry, 240, 1171-1178 (2017-09-28)
Nuts, a class of fatty natural food, are associated with a series of health benefit. Lipid, which is the most abundant nutrient in nuts, could be one of the major contributors to many beneficial effects. In previous studies, only the
Zhen Chen et al.
Theriogenology, 144, 56-66 (2020-01-10)
A comparative lipidomic profiling analysis of dairy cattle oocytes with different developmental competences was performed using a combination of high performance liquid chromatography-high resolution tandem mass spectrometry and multivariate statistical analysis. Significant lipidomic changes were identified in degenerating oocytes. Total

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