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810270P

Avanti

C11 TopFluor™ Ceramide-1-Phosphate

N-[11-(dipyrrometheneboron difluoride)undecanoyl]-D-erythro-sphingosine-1-phosphate (ammonium salt), powder

Synonym(s):

N-[11-(TopFluor)undecanoyl]-D-ceramide-1-phosphate (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C42H74BF2N4O6P
CAS Number:
2260795-50-2
Molecular Weight:
810.84
UNSPSC Code:
12352211
NACRES:
NA.25

Assay

>99% (TLC)

form

powder

packaging

pkg of 1 × 250 μg (810270P-250ug)

manufacturer/tradename

Avanti Research™ - A Croda Brand 810270P

shipped in

dry ice

storage temp.

−20°C

General description

Ceramide-1-phosphate (C1P), an anti-apoptotic lipid is produced with the help of ceramide kinase (CERK) by the direct phosphorylation of ceramide.
The availability of this new fluorescent metabolite provides the researcher with new ways to track cell migration and G protein coupled activity.

Application

C11 TopFluor™ Ceramide-1-Phosphate may be used to study its effect on the migration of pancreatic cancer stem cells (PCSC) using confocal microscopy.

Biochem/physiol Actions

Ceramide-1-phosphate (C1P) is capable of blocking cell death in bone marrow-derived macrophages (BMDMs). It controls the growth and survival in various cell types. C1P bioactive sphingolipid is known to modulate the proliferation and differentiation of photoreceptors. C1P controls apoptosis. It acts as a pro-inflammatory agent and plays a key role in phagocytosis. Ceramide-1-phosphate is well known as a second messenger and an important mediator of inflammatory response.

Packaging

5 mL Amber Glass Screw Cap Vial (810270P-250ug)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC
TopFluor is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

JAN Code

810270P-VAR:
810270P-BULK:
810270P-250UG:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Ceramide and ceramide 1-phosphate in health and disease
Arana L, et al.
Lipids in Health and Disease, 9(1), 1-12 (2010)
The Role of Ceramide-1-Phosphate in Biological Functions
Handbook of Experimental Pharmacology, 153-153 (2013)
Carolyn M Shirey et al.
Chemistry and physics of lipids, 200, 32-41 (2016-10-26)
Ceramide-1-phosphate (C1P) is an important signaling sphingolipid and a metabolite of ceramide. C1P contains an anionic phosphomonoester head group and has been shown to regulate physiological and pathophysiological processes such as cell proliferation, inflammation, apoptosis, phagocytosis, and macrophage chemotaxis. Despite
Ceramide-1-Phosphate, a New Mediator of Development and Survival in Retina Photoreceptors
Miranda GE, et al.
Investigative Ophthalmology & Visual Science, 52(9), 6580-6588 (2011)
Ceramide-1-phosphate in cell survival and inflammatory signaling
Gomez MA, et al.
Advances in Experimental Medicine and Biology, 118-130 (2010)
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