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548081

Sigma-Aldrich

2,4-Difluorobenzenesulfonyl chloride

97%

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About This Item

Linear Formula:
F2C6H3SO2Cl
CAS Number:
13918-92-8
Molecular Weight:
212.60
MDL number:
MFCD00042481
UNSPSC Code:
12352100
PubChem Substance ID:
24879012
NACRES:
NA.22

Assay

97%

refractive index

n20/D 1.518 (lit.)

bp

236-237 °C (lit.)

density

1.581 g/mL at 25 °C (lit.)

SMILES string

Fc1ccc(c(F)c1)S(Cl)(=O)=O

InChI

1S/C6H3ClF2O2S/c7-12(10,11)6-2-1-4(8)3-5(6)9/h1-3H

InChI key

FJSAJUXIHJIAMD-UHFFFAOYSA-N

General description

2,4-Difluorobenzenesulfonyl chloride is an aryl sulfonyl chloride derivative.

Application

2,4-Difluorobenzenesulfonyl chloride may be used in the preparation of 2,4-difluoro-N,N-dimethylbenzenesulfonamide, a precursor for poly(aryl ether sulfonamide)s.
It may be used in the preparation of the following benzenesulfonamide quinoline derivatives with potent anti-HIV-1 (human immunodeficiency virus type 1) activity:
  • 2,4-difluoro-N-methyl-N-(quinolin-8-yl)benzenesulfonamide
  • N-ethyl-2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide
  • 2,4-difluoro-N-(quinolin-8-yl)benzenesulfonamide

Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Flash Point(F)

230.0 °F - closed cup

Flash Point(C)

110 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Listings

Regulatory Listings are mainly provided for chemical products. Only limited information can be provided here for non-chemical products. No entry means none of the components are listed. It is the user’s obligation to ensure the safe and legal use of the product.

FSL

Group 4: Flammable liquids
Type 3 petroleums
Hazardous rank III
Water insoluble liquid

JAN Code

548081-VAR:
548081-25G:
548081-5G:
548081-BULK:

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Fudi Zhong et al.
Organic & biomolecular chemistry, 13(6), 1792-1799 (2014-12-17)
Human immunodeficiency virus type 1 (HIV-1) Rev protein facilitates the export of viral RNA from nucleus to cytoplasm, which is a key step in HIV-1 pathogenesis and transmission. In this study, we have screened a commercial library and identified the
Sulfonamide as an Activating Group for the Synthesis of Poly (aryl ether sulfonamide) s by Nucleophilic Aromatic Substitution.
Rebeck NT and Knauss DM.
Macromolecules, 44(17), 6717-6723 (2011)

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