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Merck

CYP46A1

cytochrome P450, family 46, subfamily A, polypeptide 1

Synonyms:
CP46, CYP46
Species:
Human CYP46A1 (10858), Mouse Cyp46a1 (13116), Rat Cyp46a1 (362782), chicken CYP46A1 (423450), Zebrafish cyp46a1 (553543), cow CYP46A1 (506438), dog CYP46A1 (480432)
UniProtKB ID:
Q9Y6A2
Gene ID:
  • Human(10858) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008]
  • Mouse(13116) cytochrome P450, family 46, subfamily a, polypeptide 1
  • Rat(362782) cytochrome P450, family 46, subfamily a, polypeptide 1
  • chicken(423450) cytochrome P450, family 46, subfamily A, polypeptide 1
  • Zebrafish(553543) cytochrome P450, family 46, subfamily A, polypeptide 1
  • cow(506438) cytochrome P450, family 46, subfamily A, polypeptide 1
  • dog(480432) cytochrome P450, family 46, subfamily A, polypeptide 1

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Antibodies

Product Number
Description
Species Reactivity
Application
ZRB2671
Anti-CYP46A1 Antibody, clone 1C20 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
human, monkey, mouse
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
SAB1404872
Monoclonal Anti-CYP46A1 antibody produced in mouse, clone 2B5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunoprecipitation (IP)
western blot
SAB2100523
Anti-CYP46A1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, goat, guinea pig, horse, human, mouse, rat
Application
western blot
SAB1410134
Anti-CYP46A1 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
MAB2259
Anti-Cholesterol-24 Hydroxylase Antibody, clone1A7, clone 1A7, from mouse,
Species Reactivity
human, mouse, rabbit, rat
Application
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
western blot

esiRNA

Product Number
Description
Species
EHU130401
MISSION® esiRNA, targeting human CYP46A1,
Species
human
EMU041091
MISSION® esiRNA, targeting mouse Cyp46a1,
Species
mouse