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Merck

CACNA2D2

calcium channel, voltage-dependent, alpha 2/delta subunit 2

Synonyms:
CACNA2D, LUAC11.1
Species:
UniProtKB ID:
Gene ID:
  • Human(9254) Summary: This gene encodes a member of the alpha-2/delta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. Research on a highly similar protein in rabbit suggests the protein described in this record is cleaved into alpha-2 and delta subunits. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Mouse(56808) calcium channel, voltage-dependent, alpha 2/delta subunit 2
  • Rat(300992) calcium channel, voltage-dependent, alpha 2/delta subunit 2
  • sheep(101115165) calcium channel, voltage-dependent, alpha 2/delta subunit 2
  • domestic cat(101095887) calcium channel, voltage-dependent, alpha 2/delta subunit 2
  • cow(785909) calcium channel, voltage-dependent, alpha 2/delta subunit 2
  • chicken(430150) calcium channel, voltage-dependent, alpha 2/delta subunit 2
  • Zebrafish(541376) calcium channel, voltage-dependent, alpha 2/delta subunit 2
  • dog(100688870) calcium channel, voltage-dependent, alpha 2/delta subunit 2
  • naked mole-rat(101710707) calcium channel, voltage-dependent, alpha 2/delta subunit 2
  • domestic guinea pig(100734097) calcium channel, voltage-dependent, alpha 2/delta subunit 2

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Gabapentin, United States Pharmacopeia (USP) Reference Standard,
Species
human
Gabapentin solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®,
Species
human
Gabapentin, European Pharmacopoeia (EP) Reference Standard,
Species
human
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-CACNA2D2 antibody produced in mouse, clone 3A4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
Anti-CACNA2D2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-CACNA2D2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence

Small Molecule - Blocker

Product Number
Description
Species
Bepridil hydrochloride, powder,
Species
human
Terodiline hydrochloride, ≥98% (HPLC), solid,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CACNA2D2,
Species
human