APAF1
apoptotic peptidase activating factor 1
Synonyms:
APAF-1, CED4
Species:
Human APAF1 (317), Mouse Apaf1 (11783), Rat Apaf1 (78963), dog APAF1 (482620), naked mole-rat Apaf1 (101706721), Horse APAF1 (100052552), cow APAF1 (537782), sheep APAF1 (100135699), domestic guinea pig Apaf1 (100719903), Zebrafish apaf1 (58131) ...More
UniProtKB ID:
Gene ID:
- Human(317) Summary: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(11783) apoptotic peptidase activating factor 1
- Rat(78963) apoptotic peptidase activating factor 1
- dog(482620) apoptotic peptidase activating factor 1
- naked mole-rat(101706721) apoptotic peptidase activating factor 1
- Horse(100052552) apoptotic peptidase activating factor 1
- cow(537782) apoptotic peptidase activating factor 1
- sheep(100135699) apoptotic peptidase activating factor 1
- domestic guinea pig(100719903) apoptotic peptidase activating factor 1
- Zebrafish(58131) apoptotic protease activating factor 1
- chicken(417926) apoptotic peptidase activating factor 1
- domestic cat(768257) apoptotic peptidase activating factor 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-APAF-1-ALT antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Apaf-1 Antibody, NT, Chemicon®, from rabbit,
Species Reactivity
human, mouse
Application
western blot
Anti-Apaf-1 Antibody, CT, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot
Anti-APAF1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-APAF1 antibody produced in chicken, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human, mouse
Application
western blot
