ABCB1
ATP-binding cassette, sub-family B (MDR/TAP), member 1
Synonyms:
ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1
Species:
Human ABCB1 (5243), dog ABCB1 (403879), domestic cat ABCB1 (493707), Thale Cress ABCB1 (818265), naked mole-rat Abcb1 (101702843), domestic guinea pig Abcb1 (100733532), Domestic Rabbit ABCB1 (100008914), sheep ABCB1 (443367), Horse ABCB1 (100034074), cow ABCB1 (281585)
UniProtKB ID:
Gene ID:
- Human(5243) Summary: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008]
- dog(403879) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic cat(493707) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Thale Cress(818265) ABC transporter B family member 1
- naked mole-rat(101702843) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- domestic guinea pig(100733532) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Domestic Rabbit(100008914) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- sheep(443367) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- Horse(100034074) ATP-binding cassette, sub-family B (MDR/TAP), member 1
- cow(281585) ATP-binding cassette, sub-family B (MDR/TAP), member 1
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Small Molecule - Agonist
Product Number
Description
Species
Hydrocortisone solution, 50 μM, sterile-filtered, BioXtra, suitable for cell culture,
Species
human, mouse, rat
Hydrocortisone, γ-irradiated, powder, BioXtra, suitable for cell culture,
Species
human, mouse, rat
Small Molecule - Antagonist
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-MDR1 Antibody, clone UIC2, azide free, clone UIC2, Chemicon®, from mouse,
Species Reactivity
human, primate
Application
flow cytometry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
Anti-MDR1 Antibody, conformational extracellular epitope, clone UIC2, clone UIC2, Chemicon®, from mouse,
Species Reactivity
human, primate
Application
flow cytometry
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
Anti-MDR1 Antibody, clone JSB-1, culture supernatant, clone JSB-1, Chemicon®,
Species Reactivity
hamster, human
Application
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-P-Glycoprotein Mouse mAb (C219), liquid, clone C219, Calbiochem®,
Species Reactivity
hamster, human, mouse, rat
Application
Anti-ABCB1 antibody produced in rabbit FITC conjugated, affinity isolated antibody,
Species Reactivity
bovine, canine, guinea pig, horse, human, mouse, pig, rabbit, sheep, zebrafish
Application
immunohistochemistry
Cell Lines
Product Number
Description
Species
Kits
Product Number
Description
Species
Small Molecule - Mixed Agonist/Antagonist
Product Number
Description
Species
Progesterone-Water Soluble, powder, BioReagent, suitable for cell culture,
Species
mouse, human, rat
Dexamethasone, powder, γ-irradiated, BioXtra, suitable for cell culture, ≥80% (HPLC),
Species
mouse, rat, human
Proteins
Product Number
Description
Species
SB-MDR1-Hi5-PREDEASY-ATPase kit, membrane based kit for Human MDR1 ATPase Transport Assays,
Species
human
esiRNA
Product Number
Description
Species