933554
NanoFabTx™ NTA Lipid Mix
for synthesis of NTA-functionalized liposomes for small molecule delivery
Synonym(s):
Cholesterol, DGS-NTA(Ni), HSPC, PEG-DSPE
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About This Item
UNSPSC Code:
12352211
NACRES:
NA.21
Recommended Products
Quality Level
storage temp.
−20°C
Application
NanoFabTx™ NTA Lipid Mix is a ready-to-use nanoformulation lipid mixture for the synthesis of NTA-functionalized liposomes. This lipid mix enables users to encapsulate a wide variety of small molecules for targeting and immunotherapy applications without the need for lengthy trial-and-error optimization.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with NTA groups using extrusion and microfluidics are also included. The synthesized NTA-functionalized liposomes enable the conjugation of His-tagged antibodies or proteins to the liposomes surface for immunothereapy applications and multi-targeting or multi-type cargo delivery.
This product includes a curated lyophilized lipid mixture containing rationally selected lipids in precise ratios that have been optimized to achieve a desired size range of liposomes. Step-by-step protocols for the synthesis of liposomes surface-functionalized with NTA groups using extrusion and microfluidics are also included. The synthesized NTA-functionalized liposomes enable the conjugation of His-tagged antibodies or proteins to the liposomes surface for immunothereapy applications and multi-targeting or multi-type cargo delivery.
Features and Benefits
- A ready-to-use nanoformulation lipid blend for the synthesis of NTA-functionalized liposomes
- Step-by-step extrusion and microfluidics protocols for liposome synthesis developed and tested by our formulation scientists
- Flexible synthesis methods to create uniform and reproducible liposomes
- Protocols and lipid blend optimized to make liposomes around 100 nm diameter with low polydispersity
- Lipid mix optimized for His-tagged protein or antibody conjugation and small molecule encapsulation
- A lipid film hydration and extrusion protocol
- A microfluidics protocol using commercial platforms or syringe pumps
Legal Information
NANOFABTX is a trademark of Sigma-Aldrich Co. LLC
TMAX is a trademark of Merck KGaA, Darmstadt, Germany
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Certificates of Analysis (COA)
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Mitsuru Ando et al.
Advanced science (Weinheim, Baden-Wurttemberg, Germany), 5(10), 1800524-1800524 (2018-10-26)
Integral membrane proteins (IMPs) modulate key cellular processes; their dysfunctions are closely related to disease. However, production of IMPs in active conformations for further study is hindered by aggregation and toxicity in living expression systems. IMPs are therefore produced in
Mesoscale active matter in fluids
Klotsa, Daphne
Soft Matter (2019)
Encapsulation of hydrophobic components in dendrimersomes and decoration of their surface with proteins and nucleic acids
Torre, Paola, et al.
Proceedings of the National Academy of Sciences (2019)
Zhilin Chen et al.
Bioconjugate chemistry, 29(4), 1251-1260 (2018-03-13)
The number and spacing of B-cell epitopes on antigens have a profound impact on the activation of B cells and elicitation of antibody responses, the quantitative aspects of which may be utilized for rational design of vaccines. Ni-chelating liposomes have
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