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283320

Sigma-Aldrich

Butyl lactate

98%

Synonym(s):

α-Hydroxypropionic acid butyl ester, (±)-n-Butyl lactate, 2-Hydroxypropanoic acid butyl ester, Butyl α-hydroxypropionate, Butyl 2-hydroxypropanoate, n-Butyl lactate

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About This Item

Linear Formula:
CH3CH(OH)CO2(CH2)3CH3
CAS Number:
138-22-7
Molecular Weight:
146.18
EC Number:
205-316-4
MDL number:
MFCD00004519
UNSPSC Code:
12352100
PubChem Substance ID:
24857101
NACRES:
NA.22

vapor density

5.04 (vs air)

vapor pressure

0.4 mmHg ( 20 °C)

Assay

98%

form

liquid

refractive index

n20/D 1.421 (lit.)

bp

185-187 °C (lit.)

mp

−28 °C (lit.)

density

0.984 g/mL at 25 °C (lit.)

SMILES string

CCCCOC(=O)C(C)O

InChI

1S/C7H14O3/c1-3-4-5-10-7(9)6(2)8/h6,8H,3-5H2,1-2H3

InChI key

MRABAEUHTLLEML-UHFFFAOYSA-N

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Application

Butyl lactate has been used:
  • in the preparation of solid lipid nanoparticles by a solvent emulsification–diffusion technique
  • in the synthesis of nanoparticles of griseofulvin from water dilutable microemulsions by the solvent diffusion technique
  • as cosurfactant on the preparation of microemulsions with anionic surfactant

Storage Class Code

10 - Combustible liquids

WGK

WGK 2

Flash Point(F)

156.2 °F - closed cup

Flash Point(C)

69 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Michele Trotta et al.
International journal of pharmaceutics, 257(1-2), 153-160 (2003-04-25)
A preparation method for nanoparticles based on the emulsification of a butyl lactate or benzyl alcohol solution of a solid lipid in an aqueous solution of different emulsifiers, followed by dilution of the emulsion with water, was used to prepare
Michele Trotta et al.
International journal of pharmaceutics, 254(2), 235-242 (2003-03-08)
Nanoparticles of griseofulvin, a model drug with poor solubility and low bioavailability, were prepared from water dilutable microemulsions by the solvent diffusion technique. Solvent-in-water microemulsion formulations containing water, butyl lactate, lecithin, taurodeoxycholate sodium salt (TDC) or dipotassium glycyrrhizinate (KG), 1,2-propanediol
Domenico Pirozzi et al.
Biotechnology progress, 22(2), 444-448 (2006-04-08)
The alpha-hydroxy esters are increasingly employed in cosmetic, food, and pharmaceutical formulations as they determine reduced skin-irritant effects in comparison with the respective acids, offering similar hygroscopic, emulsifying, and exfoliating properties. The enzymatic synthesis of lactate esters in nonaqueous systems
Daniela Chirio et al.
International journal of molecular sciences, 19(12) (2018-12-06)
Chitosan is an excipient which has been studied thoroughly in research works thanks to its positive characteristics such as muco-adhesiveness and ability to open epithelial-tight-junctions. In this article, lipophilic stearoyl chitosan (ST-CS) was synthetized in order to anchor this polymer
Hitomi Ohara et al.
Journal of bioscience and bioengineering, 111(1), 19-21 (2010-09-21)
n-Butyl D- and L-lactates (BuDLa and BuLLa) were incubated with immobilized lipase. (1)H-NMR showed that BuDLa reacted to oligomers, while BuLLa did not react. A mixture containing 90.4% of BuLLa and 9.6% of BuDLa was incubated with the enzyme for
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