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L0745000

Lomustine

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea

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About This Item

Empirical Formula (Hill Notation):
C9H16ClN3O2
CAS Number:
13010-47-4
Molecular Weight:
233.70
MDL number:
MFCD00012392
UNSPSC Code:
41116107
PubChem Substance ID:
329817373
NACRES:
NA.24

grade

pharmaceutical primary standard

API family

lomustine

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

ClCCN(N=O)C(=O)NC1CCCCC1

InChI

1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)

InChI key

GQYIWUVLTXOXAJ-UHFFFAOYSA-N

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General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Lomustine EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biochem/physiol Actions

Antineoplastic agent with cellular DNA effects. Lomustine induces p53 expression in A2870 cells.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H350

Precautionary Statements

P201 - P301 + P310 + P330

Hazard Classifications

Acute Tox. 3 Oral - Carc. 1B

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Preliminary study of lomustine in the treatment of intracranial masses in dogs following localization by imaging techniques.
L M Fulton et al.
Seminars in veterinary medicine and surgery (small animal), 5(4), 241-245 (1990-11-01)
The role of an all-oral chemotherapy containing lomustine (CCNU) in advanced,fs progressive Hodgkin lymphoma: a patient-friendly palliative option which can result in long-term disease control.
S J Proctor et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 21(2), 426-428 (2009-11-11)
G A Kaltsas et al.
Clinical endocrinology, 57(2), 169-183 (2002-08-03)
Combination chemotherapy with the two agents streptozotocin (SZT), which is a nitrosurea, and 5-fluorouracil (5-FU), an alkylating agent, has a long-established role in the treatment of neuroendocrine tumours; however, it is often accompanied by considerable toxicity, and it has not
The nitrosoureas: carmustine (BCNU) and lomustine (CCNU).
R B Weiss et al.
Cancer treatment reviews, 9(4), 313-330 (1982-12-01)

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