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03-5300

Sigma-Aldrich

Butyric acid

SAJ special grade, ≥99.5%

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About This Item

Linear Formula:
CH3CH2CH2COOH
CAS Number:
107-92-6
Molecular Weight:
88.11
Beilstein:
906770
MDL number:
MFCD00002814
UNSPSC Code:
12352106
PubChem Substance ID:
329747729

grade

SAJ special grade

vapor density

3.04 (vs air)

vapor pressure

0.43 mmHg ( 20 °C)

Assay

≥99.5%

form

liquid

autoignition temp.

824 °F

expl. lim.

10 %

availability

available only in Japan

refractive index

n20/D 1.398 (lit.)

pH

2 (25 °C, 10 g/L)
3 (20 °C, 10 g/L)

pKa (20.7 °C)

4.9

bp

162 °C (lit.)

mp

−6-−3 °C (lit.)

density

0.964 g/mL at 25 °C (lit.)

SMILES string

CCCC(O)=O

InChI

1S/C4H8O2/c1-2-3-4(5)6/h2-3H2,1H3,(H,5,6)

InChI key

FERIUCNNQQJTOY-UHFFFAOYSA-N

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Pictograms

CorrosionExclamation mark
GHS05,GHS07

Signal Word

Danger

Hazard Statements

H302,H314,H335

Hazard Classifications

Acute Tox. 4 Oral - Eye Dam. 1 - Skin Corr. 1B - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 1

Flash Point(F)

167.0 °F

Flash Point(C)

75 °C

Certificates of Analysis (COA)

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Shomik Sengupta et al.
Journal of gastroenterology and hepatology, 21(1 Pt 2), 209-218 (2006-02-08)
Butyrate, the four-carbon fatty acid, is formed in the human colon by bacterial fermentation of carbohydrates (including dietary fiber), and putatively suppresses colorectal cancer (CRC). Butyrate has diverse and apparently paradoxical effects on cellular proliferation, apoptosis and differentiation that may
Carlo F M Welters et al.
Diseases of the colon and rectum, 45(5), 621-627 (2002-05-11)
Inflammation is a constant finding in the ileal reservoir of patients with an ileal pouch-anal anastomosis and is associated with decreased fecal concentrations of the short chain fatty acid butyrate, increased fecal pH, changes in fecal flora, and increased concentrations
Hans G Cruz et al.
Nature neuroscience, 7(2), 153-159 (2004-01-28)
The rewarding effect of drugs of abuse is mediated by activation of the mesolimbic dopamine system, which is inhibited by putative anti-craving compounds. Interestingly, different GABA(B) receptor agonists can exert similarly opposing effects on the reward pathway, but the cellular
Ada Rephaeli et al.
International journal of cancer, 116(2), 226-235 (2005-04-01)
AN-7, a prodrug of butyric acid, induced histone hyperacetylation and differentiation and inhibited proliferation of human prostate 22Rv1 cancer cells in vitro and in vivo. In nude mice implanted with these cells, 50 mg/kg AN-7 given orally thrice a week
Svenja Plöger et al.
Annals of the New York Academy of Sciences, 1258, 52-59 (2012-06-27)
Butyrate production in the large intestine and ruminant forestomach depends on bacterial butyryl-CoA/acetate-CoA transferase activity and is highest when fermentable fiber and nonstructural carbohydrates are balanced. Gastrointestinal epithelia seem to use butyrate and butyrate-induced endocrine signals to adapt proliferation, apoptosis
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