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Key Documents

FCMAB389F

Sigma-Aldrich

Milli-Mark® Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4

clone HUTS-4, Milli-Mark®, from mouse

Synonym(s):

Ligand-induced Binding Site, LIBS, CLIBS

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

FITC conjugate

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

HUTS-4, monoclonal

species reactivity

human

manufacturer/tradename

Milli-Mark®

technique(s)

flow cytometry: suitable

isotype

IgG2b

NCBI accession no.

NP_002202

UniProt accession no.

P05556

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGB1(3688)

General description

Integrin beta 1, also known as CD29, is a 130 kDa transmembrane glycoprotein that forms noncovalent complexes with various Integrin alpha subunits 1 to 6 (CD49a to CD49f) also known as Very Late Antigens (VLA). CD29 is also called platelet GPIIa. The antigen mediates cellular adhesion and has broad cellular reactivity, but is not expressed by erythrocytes. In normal peripheral blood it is found on a subset of CD4+ and CD8+ T lymphocytes and on a minority of B lymphocytes. The "inducer" subpopulation of CD4+ lymphocytes co-express CD4 and CD29.

Application

Milli-Mark Anti-Integrin β1-FITC Antibody, activated, clone HUTS-4 is an antibody against Integrin β1 for use in FC.

Quality

Evaluated by flow cytometry using A431 cells.

Target description

88 kDa Calculated

Other Notes

Unconjugated antibody Cat. No. MAB2079Z is known to react with Rat.

Legal Information

MILLI-MARK is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Meller et al.
Journal of thrombosis and haemostasis : JTH, 10(7), 1397-1408 (2012-05-09)
Kindlin-3 is a novel integrin activator in hematopoietic cells, and its deficiency leads to immune problems and severe bleeding, known as leukocyte adhesion deficiency III (LAD-III). Our current understanding of Kindlin-3 function primarily relies on analysis of animal models or
Dwayne A L Vickers et al.
PloS one, 8(6), e65828-e65828 (2013-06-14)
Adhesion-based microfluidic cell separation has proven to be very useful in applications ranging from cancer diagnostics to tissue engineering. This process involves functionalizing microchannel surfaces with a capture molecule. High specificity and purity capture can be achieved using this method.
Marleen Leidecker et al.
Microbiology spectrum, 11(3), e0388622-e0388622 (2023-03-31)
Invasion of host cells is an important feature of Staphylococcus aureus. The main internalization pathway involves binding of the bacteria to host cells, e.g., endothelial cells, via a fibronectin (Fn) bridge between S. aureus Fn binding proteins and α5β1-integrin, followed
Dasom Shin et al.
Nature communications, 15(1), 2789-2789 (2024-03-31)
Proprotein convertase subtilisin/kexin type-9 (PCSK9) binds to and degrades low-density lipoprotein (LDL) receptor, leading to increase of LDL cholesterol in blood. Its blockers have emerged as promising therapeutics for cardiovascular diseases. Here we show that PCSK9 itself directly induces inflammation

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