- High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway.
High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway.
Scientific reports (2017-11-03)
Ouyang Chen, Zhiyong Cao, He Li, Zhouheng Ye, Rongjia Zhang, Ning Zhang, Junlong Huang, Ting Zhang, Liping Wang, Ling Han, Wenwu Liu, Xuejun Sun
PMID29093541
ABSTRACT
The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH). C57BL/6 mice were randomly divided into the following groups: sham, I/R, I/R + HCH, I/R + HCH + LY294002 (PI3K inhibitor), I/R + HCH + wortmannin (PI3K inhibitor), I/R + LY294002, and I/R + wortmannin. After 45 min of ischemia, HCH (67% H
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